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HomoloGene:1483. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

EGF,  H.sapiens
epidermal growth factor
NP_001954.2
1207 aa
EGF,  P.troglodytes
epidermal growth factor
XP_517395.2
1207 aa
EGF,  M.mulatta
epidermal growth factor
XP_001088957.1
1208 aa
EGF,  C.lupus
epidermal growth factor
NP_001003094.1
1216 aa
EGF,  B.taurus
epidermal growth factor
XP_002688149.2
1220 aa
Egf,  M.musculus
epidermal growth factor
NP_034243.2
1217 aa
Egf,  R.norvegicus
epidermal growth factor
NP_036974.1
1133 aa
EGF,  G.gallus
epidermal growth factor
NP_001001292.1
1245 aa
egf,  X.tropicalis
epidermal growth factor
NP_001106478.1
1051 aa
egf,  D.rerio
epidermal growth factor
NP_991294.1
1114 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hypomagnesemia 4, renal.



Publications
Articles associated with genes and sequences of this homology group.

Epidermal growth factor modulates voltage sensitivity of slow sodium channels.
Plakhova VB, et al. Dokl Biol Sci 450, 123-5 (2013).
Aldosterone induces myofibroblast EGF secretion to regulate epithelial colonic permeability.
Miró L, et al. Am J Physiol Cell Physiol 304, C918-26 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PHA03099 (PHA03099)
  epidermal growth factor-like protein (EGF-like protein); Provisional.
EGF_3 (pfam12947)
  EGF domain.
Ldl_recept_b (cl10508)
  Low-density lipoprotein receptor repeat class B.
LY (smart00135)
  Low-density lipoprotein-receptor YWTD domain.
Ldl_recept_b (pfam00058)
  Low-density lipoprotein receptor repeat class B.
EGF_CA (pfam07645)
  Calcium-binding EGF domain.
cEGF (pfam12662)
  Complement Clr-like EGF-like.
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
Ldl_recept_b (pfam00058)
  Low-density lipoprotein receptor repeat class B.
EGF_3 (pfam12947)
  EGF domain.
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Egf includes H.sapiens EGF and R.norvegicus Egf.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (5 transcripts, 5 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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