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HomoloGene:55469. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

LDLR,  H.sapiens
low density lipoprotein receptor
860 aa
LDLR,  P.troglodytes
low density lipoprotein receptor
860 aa
LDLR,  M.mulatta
low density lipoprotein receptor
853 aa
LDLR,  C.lupus
low density lipoprotein receptor
863 aa
LDLR,  B.taurus
low density lipoprotein receptor
845 aa
Ldlr,  M.musculus
low density lipoprotein receptor
862 aa
Ldlr,  R.norvegicus
low density lipoprotein receptor
879 aa
LOC100495826,  X.tropicalis
low-density lipoprotein receptor 1-like
894 aa
ldlra,  D.rerio
low density lipoprotein receptor a
911 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Hypercholesterolemia, familial.

Articles associated with genes and sequences of this homology group.

A variant in LDLR is associated with abdominal aortic aneurysm.
Bradley DT, et al. Circ Cardiovasc Genet 6, 498-504 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ldl_recept_b (cl10508)
  Low-density lipoprotein receptor repeat class B.
LY (smart00135)
  Low-density lipoprotein-receptor YWTD domain.
Ldl_recept_b (pfam00058)
  Low-density lipoprotein receptor repeat class B.
cEGF (pfam12662)
  Complement Clr-like EGF-like.
Ldl_recept_b (pfam00058)
  Low-density lipoprotein receptor repeat class B.
LDLa (cl00104)
  Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ldlr includes H.sapiens LDLR and R.norvegicus Ldlr.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (10 transcripts, 8 species)
Amphibia - amphibians (2 transcripts, 2 species)

Insecta - insects (5 transcripts, 4 species)
Arachnida - arachnids (1 transcript, 1 species)

Gastropoda - gastropods (1 transcript, 1 species)

Polychaeta - segmented worms (1 transcript, 1 species)




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