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HomoloGene:446. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

OTC,  H.sapiens
ornithine carbamoyltransferase
NP_000522.3
354 aa
OTC,  C.lupus
ornithine carbamoyltransferase
XP_537995.1
354 aa
OTC,  B.taurus
ornithine carbamoyltransferase
NP_803453.1
354 aa
Otc,  M.musculus
ornithine transcarbamylase
NP_032795.1
354 aa
Otc,  R.norvegicus
ornithine carbamoyltransferase
NP_037210.1
354 aa
OTC,  G.gallus
ornithine carbamoyltransferase
NP_990241.1
354 aa
otc,  X.tropicalis
ornithine carbamoyltransferase
NP_001005795.1
351 aa
otc,  D.rerio
ornithine carbamoyltransferase
XP_001334671.1
352 aa
ARG3,  S.cerevisiae
ARG3
NP_012447.1
338 aa
KLLA0F14366g,  K.lactis
KLLA0F14366g
XP_455725.1
334 aa
AGOS_AFR098W,  E.gossypii
AGOS_AFR098W
NP_985645.1
349 aa
arg3,  S.pombe
arg3
NP_593692.1
327 aa
MGG_01102,  M.oryzae
MGG_01102
XP_003717832.1
351 aa
NCU01667,  N.crassa
NCU01667
XP_956873.2
359 aa
OTC,  A.thaliana
OTC
NP_177667.1
375 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Ornithine transcarbamylase deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Ornithine Transcarbamylase Deficiency
Lichter-Konecki U, et al. (1993).
Neurotransmitter receptor alterations in hepatic encephalopathy: a review.
Palomero-Gallagher N & Zilles K. Arch Biochem Biophys 536, 109-21 (2013).
Serum ornithine carbamyltransferase reflects hepatic damage in diabetic obese mice.
Murayama H, et al. J Gastroenterol Hepatol 25, 413-9 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
OTCace (pfam00185)
  Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain.
OTCace_N (pfam02729)
  Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain.
OTCace (pfam00185)
  Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain.
OTCace_N (pfam02729)
  Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Otc includes H.sapiens OTC and R.norvegicus Otc.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (37 transcripts, 31 species)
Liliopsida - monocots (11 transcripts, 9 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Chordata
Mammalia - mammals (11 transcripts, 11 species)
Actinopterygii - bony fishes (7 transcripts, 7 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (11 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Oomycetes
Pythiales - oomycetes (2 transcripts, 1 species)
Peronosporales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

 

 

 

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