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HomoloGene:1658. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

IRF1,  H.sapiens
interferon regulatory factor 1
NP_002189.1
325 aa
IRF1,  P.troglodytes
interferon regulatory factor 1
XP_001150404.2
325 aa
IRF1,  M.mulatta
interferon regulatory factor 1
XP_001104294.1
325 aa
IRF1,  C.lupus
interferon regulatory factor 1
XP_003639416.2
437 aa
IRF1,  B.taurus
interferon regulatory factor 1
NP_001178190.1
322 aa
Irf1,  M.musculus
interferon regulatory factor 1
NP_001152868.1
329 aa
Irf1,  R.norvegicus
interferon regulatory factor 1
NP_036723.1
328 aa
IRF1,  G.gallus
interferon regulatory factor 1
NP_990746.1
313 aa
irf1,  X.tropicalis
interferon regulatory factor 1
NP_001006695.1
302 aa
irf1b,  D.rerio
interferon regulatory factor 1b
NP_991310.1
287 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Gastric cancer.
Myelodysplastic syndrome, preleukemic.
Myelogenous leukemia, acute.
Nonsmall cell lung cancer.
Macrocytic anemia, refractory, of 5q- syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Relation between IRF-1 gene and acute myelocytic leukemia in Kashmiri population.
Khan T, et al. Asian Pac J Cancer Prev 12, 1035-9 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IRF (cl00096)
  Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Irf1 includes H.sapiens IRF1 and R.norvegicus Irf1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 14 species)
Actinopterygii - bony fishes (5 transcripts, 5 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

 

 

 

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