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HomoloGene:37749. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TK1,  H.sapiens
thymidine kinase 1, soluble
NP_003249.3
234 aa
TK1,  P.troglodytes
thymidine kinase 1, soluble
XP_003315799.1
276 aa
TK1,  M.mulatta
thymidine kinase 1, soluble
XP_001107944.2
304 aa
TK1,  C.lupus
thymidine kinase 1, soluble
XP_003639284.1
242 aa
TK1,  B.taurus
thymidine kinase 1, soluble
NP_001091041.1
238 aa
Tk1,  M.musculus
thymidine kinase 1
NP_033413.2
233 aa
Tk1,  R.norvegicus
thymidine kinase 1, soluble
NP_434687.1
232 aa
TK1,  G.gallus
thymidine kinase 1, soluble
NP_990229.1
224 aa
tk1,  X.tropicalis
thymidine kinase 1, soluble
NP_001011452.1
236 aa
tk1,  D.rerio
thymidine kinase 1, soluble
NP_956126.1
230 aa
LOC100537847,  D.rerio
thymidine kinase, cytosolic-like
XP_003199583.1
230 aa
thk-1,  C.elegans
thk-1
NP_001255477.1
269 aa
AT5G23070,  A.thaliana
AT5G23070
NP_568426.1
282 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Elevated serum thymidine kinase 1 predicts risk of pre/early cancerous progression.
Huang S, et al. Asian Pac J Cancer Prev 12, 497-505 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
P-loop_NTPase (cl09099)
  P-loop containing Nucleoside Triphosphate Hydrolases.
TK (pfam00265)
  Thymidine kinase.
AAA (cl18944)
  The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tk1 includes H.sapiens TK1 and R.norvegicus Tk1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 12 species)
Actinopterygii - bony fishes (11 transcripts, 9 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (13 transcripts, 13 species)
Bryopsida - mosses (1 transcript, 1 species)
Coniferopsida - conifers (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 2 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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