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HomoloGene:3209. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CD74,  H.sapiens
CD74 molecule, major histocompatibility complex, class II invariant chain
NP_001020330.1
296 aa
CD74,  P.troglodytes
CD74 molecule, major histocompatibility complex, class II invariant chain
NP_001138308.1
232 aa
CD74,  M.mulatta
CD74 molecule, major histocompatibility complex, class II invariant chain
XP_001099491.2
327 aa
CD74,  C.lupus
CD74 molecule, major histocompatibility complex, class II invariant chain
XP_536468.5
272 aa
Cd74,  M.musculus
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
NP_001036070.1
279 aa
Cd74,  R.norvegicus
Cd74 molecule, major histocompatibility complex, class II invariant chain
NP_037201.1
216 aa
CD74,  G.gallus
CD74 molecule, major histocompatibility complex, class II invariant chain
NP_001001613.1
286 aa
cd74,  X.tropicalis
CD74 molecule, major histocompatibility complex, class II invariant chain
NP_001184039.1
291 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

CD74: a potential novel target for triple-negative breast cancer.
Tian B, et al. Tumour Biol 33, 2273-7 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MHCassoc_trimer (pfam08831)
  Class II MHC-associated invariant chain trimerisation domain.
MHC2-interact (pfam09307)
  CLIP, MHC2 interacting.
MHC2-interact (pfam09307)
  CLIP, MHC2 interacting.
TY (cl00150)
  Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cd74 includes H.sapiens CD74 and R.norvegicus Cd74.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 13 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)

Streptophyta
Eudicotyledons - eudicots (2 transcripts, 1 species)

 

 

 

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