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HomoloGene:38034. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

HCLS1,  H.sapiens
hematopoietic cell-specific Lyn substrate 1
NP_005326.2
486 aa
HCLS1,  P.troglodytes
hematopoietic cell-specific Lyn substrate 1
XP_516684.2
484 aa
HCLS1,  M.mulatta
hematopoietic cell-specific Lyn substrate 1
XP_001111514.1
475 aa
HCLS1,  C.lupus
hematopoietic cell-specific Lyn substrate 1
XP_005639607.1
487 aa
HCLS1,  B.taurus
hematopoietic cell-specific Lyn substrate 1
NP_001030229.1
485 aa
Hcls1,  M.musculus
hematopoietic cell specific Lyn substrate 1
NP_032251.2
486 aa
Hcls1,  R.norvegicus
hematopoietic cell specific Lyn substrate 1
NP_001011898.1
476 aa
HCLS1,  G.gallus
hematopoietic cell-specific Lyn substrate 1
NP_001026572.1
515 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The SH3 domain of HS1 protein recognizes lysine-rich polyproline motifs.
Siligardi G, et al. Amino Acids 42, 1361-70 (2012).
Studies on the actin-binding protein HS1 in platelets.
Thomas SG, et al. BMC Cell Biol 8, 46 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HS1_rep (pfam02218)
  Repeat in HS1/Cortactin.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
SH3 (cl17036)
  Src Homology 3 domain superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hcls1 includes H.sapiens HCLS1 and R.norvegicus Hcls1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 13 species)
Actinopterygii - bony fishes (10 transcripts, 6 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 4 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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