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HomoloGene:20078. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

FUCA1,  H.sapiens
fucosidase, alpha-L- 1, tissue
NP_000138.2
466 aa
FUCA1,  P.troglodytes
fucosidase, alpha-L- 1, tissue
XP_524607.4
448 aa
FUCA1,  M.mulatta
fucosidase, alpha-L- 1, tissue
XP_001104941.2
418 aa
FUCA1,  C.lupus
fucosidase, alpha-L- 1, tissue
NP_001003250.1
466 aa
FUCA1,  B.taurus
fucosidase, alpha-L- 1, tissue
NP_001039500.1
468 aa
Fuca1,  M.musculus
fucosidase, alpha-L- 1, tissue
NP_077205.3
452 aa
Fuca1,  R.norvegicus
fucosidase, alpha-L- 1, tissue
NP_036694.2
462 aa
FUCA1,  G.gallus
fucosidase, alpha-L- 1, tissue
XP_417835.2
451 aa
LOC100497659,  X.tropicalis
tissue alpha-L-fucosidase-like
XP_004911674.1
459 aa
fuca1,  X.tropicalis
fucosidase, alpha-L- 1, tissue
NP_001015860.1
459 aa
fuca1,  D.rerio
fucosidase, alpha-L- 1, tissue
NP_997905.1
451 aa
zgc:101116,  D.rerio
zgc:101116
NP_001003559.1
451 aa
MGG_00316,  M.oryzae
MGG_00316
XP_003718772.1
803 aa
MGG_00042,  M.oryzae
MGG_00042
XP_003719101.1
612 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Fucosidosis.



Publications
Articles associated with genes and sequences of this homology group.

Decreased expression of alpha-L-fucosidase gene FUCA1 in human colorectal tumors.
Otero-Estévez O, et al. Int J Mol Sci 14, 16986-98 (2013).
A novel FUCA1 mutation causing fucosidosis in a Chinese boy.
Ip P, et al. J Inherit Metab Dis 25, 415-6 (2002).
Spectrum of mutations in fucosidosis.
Willems PJ, et al. Eur J Hum Genet 7, 60-7 (1999).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Alpha_L_fucos (cl12119)
  Alpha-L-fucosidase.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fuca1 includes H.sapiens FUCA1 and R.norvegicus Fuca1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 15 species)
Actinopterygii - bony fishes (15 transcripts, 11 species)
Ascidiacea - tunicates (6 transcripts, 1 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 3 species)
Arachnida - arachnids (2 transcripts, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (4 transcripts, 1 species)
Hydrozoa - hydrozoans (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (5 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (4 transcripts, 1 species)

Codonosigidae
Monosiga - choanoflagellates (2 transcripts, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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