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HomoloGene:55553. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

ACTN1,  H.sapiens
actinin, alpha 1
914 aa
ACTN1,  P.troglodytes
actinin, alpha 1
1047 aa
ACTN1,  C.lupus
actinin, alpha 1
914 aa
ACTN1,  B.taurus
actinin, alpha 1
892 aa
Actn1,  M.musculus
actinin, alpha 1
892 aa
Actn1,  R.norvegicus
actinin, alpha 1
892 aa
ACTN1,  G.gallus
actinin, alpha 1
888 aa
actn1,  X.tropicalis
actinin, alpha 1
885 aa
actn1,  D.rerio
actinin, alpha 1
902 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

ACTN1 mutations cause congenital macrothrombocytopenia.
Kunishima S, et al. Am J Hum Genet 92, 431-8 (2013).
Expression of alpha-actinin-1 in human glomerular mesangial cells in vivo and in vitro.
Yang C & Glass WF 2nd. Exp Biol Med (Maywood) 233, 689-93 (2008).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Spectrin (pfam00435)
  Spectrin repeat.
efhand_Ca_insen (pfam08726)
  Ca2+ insensitive EF hand.
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
SPEC (cd00176)
  Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
EFhand_Ca_insen (pfam08726)
  Ca2+ insensitive EF hand.
CH (cl00030)
  Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
Spectrin (cl02488)
  Spectrin repeat.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Actn1 includes H.sapiens ACTN1 and R.norvegicus Actn1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (18 transcripts, 13 species)
Actinopterygii - bony fishes (16 transcripts, 9 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Insecta - insects (13 transcripts, 10 species)
Branchiopoda - crustaceans (3 transcripts, 1 species)
Arachnida - arachnids (2 transcripts, 2 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Trematoda - flatworms (7 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (2 transcripts, 1 species)

Chromadorea - nematodes (3 transcripts, 2 species)

Hirudinida - segmented worms (2 transcripts, 1 species)
Polychaeta - segmented worms (1 transcript, 1 species)

Gastropoda - gastropods (2 transcripts, 2 species)

Echinoidea - sea urchins (2 transcripts, 2 species)

Demospongiae - sponges (1 transcript, 1 species)

Eudicotyledons - eudicots (3 transcripts, 1 species)
Liliopsida - monocots (1 transcript, 1 species)




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