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HomoloGene:5168. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

VCP,  H.sapiens
valosin containing protein
NP_009057.1
806 aa
VCP,  P.troglodytes
valosin containing protein
XP_003312111.1
806 aa
VCP,  C.lupus
valosin containing protein
XP_852626.1
806 aa
VCP,  B.taurus
valosin containing protein
NP_001029466.1
806 aa
Vcp,  M.musculus
valosin containing protein
NP_033529.3
806 aa
Vcp,  R.norvegicus
valosin-containing protein
NP_446316.1
806 aa
VCP,  G.gallus
valosin containing protein
NP_001038129.1
806 aa
vcp,  X.tropicalis
valosin containing protein
NP_001005677.1
805 aa
vcp,  D.rerio
valosin containing protein
NP_958889.1
806 aa
TER94,  D.melanogaster
TER94
NP_477369.1
801 aa
AgaP_AGAP005630,  A.gambiae
AgaP_AGAP005630
XP_315644.3
804 aa
cdc-48.1,  C.elegans
cdc-48.1
NP_496273.1
809 aa
cdc-48.2,  C.elegans
cdc-48.2
NP_495705.1
810 aa
CDC48,  S.cerevisiae
CDC48
NP_010157.1
835 aa
KLLA0F05676g,  K.lactis
KLLA0F05676g
XP_455337.1
830 aa
AGOS_AFR158W,  E.gossypii
AGOS_AFR158W
NP_985705.2
832 aa
cdc48,  S.pombe
cdc48
NP_593287.2
815 aa
MGG_05193,  M.oryzae
MGG_05193
XP_003712735.1
820 aa
NCU00018,  N.crassa
NCU00018
XP_957005.2
759 aa
CDC48,  A.thaliana
CDC48
NP_187595.1
809 aa
AT5G03340,  A.thaliana
AT5G03340
NP_568114.1
810 aa
AT3G53230,  A.thaliana
AT3G53230
NP_190891.1
815 aa
Os03g0151800,  O.sativa
Os03g0151800
NP_001048987.1
809 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Inclusion body myopathy with early-onset Paget disease and frontotemporal dementia.



Publications
Articles associated with genes and sequences of this homology group.

Novel mutation in VCP gene causes atypical amyotrophic lateral sclerosis.
González-Pérez P, et al. Neurology 79, 2201-8 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Vps4_C (pfam09336)
  Vps4 C terminal oligomerization domain.
CDC48_N (pfam02359)
  Cell division protein 48 (CDC48), N-terminal domain.
CDC48_N (pfam02359)
  Cell division protein 48 (CDC48), N-terminal domain.
IL15 (pfam02372)
  Interleukin 15.
CDC48_2 (cl08380)
  This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the C-terminus. The VAT-N domain found in AAA ATPases pfam00004 is a substrate 185-residue recognition domain.
MopB_CT (cl09929)
  Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- ...
AAA (cl18944)
  The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Vcp includes H.sapiens VCP and R.norvegicus Vcp.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (109 transcripts, 34 species)
Liliopsida - monocots (31 transcripts, 9 species)
Coniferopsida - conifers (7 transcripts, 3 species)
Bryopsida - mosses (6 transcripts, 1 species)
Isoetopsida - club-mosses (3 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Chordata
Mammalia - mammals (23 transcripts, 15 species)
Actinopterygii - bony fishes (21 transcripts, 10 species)
Ascidiacea - tunicates (5 transcripts, 3 species)
Aves - birds (4 transcripts, 2 species)
Hyperoartia - vertebrates (3 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (16 transcripts, 12 species)
Arachnida - arachnids (2 transcripts, 2 species)
Malacostraca - crustaceans (2 transcripts, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (4 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (3 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)
Hirudinida - segmented worms (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (5 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (4 transcripts, 2 species)

Apicomplexa
Coccidia - apicomplexans (2 transcripts, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (3 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (2 transcripts, 1 species)

Codonosigidae
Monosiga - choanoflagellates (2 transcripts, 1 species)

 

 

 

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