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HomoloGene:14254. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

KIDINS220,  H.sapiens
kinase D-interacting substrate, 220kDa
NP_065789.1
1771 aa
KIDINS220,  P.troglodytes
kinase D-interacting substrate, 220kDa
XP_003308939.1
1731 aa
KIDINS220,  M.mulatta
kinase D-interacting substrate, 220kDa
XP_001083478.1
1771 aa
KIDINS220,  C.lupus
kinase D-interacting substrate, 220kDa
XP_532865.3
1772 aa
KIDINS220,  B.taurus
kinase D-interacting substrate, 220kDa
XP_003586702.1
1770 aa
Kidins220,  M.musculus
kinase D-interacting substrate 220
NP_001074847.1
1793 aa
Kidins220,  R.norvegicus
kinase D-interacting substrate 220
NP_446247.1
1762 aa
KIDINS220,  G.gallus
kinase D-interacting substrate, 220kDa
XP_419939.2
1783 aa
kidins220,  X.tropicalis
kinase D-interacting substrate, 220kDa
NP_001120159.1
1741 aa
kidins220b,  D.rerio
kinase D-interacting substrate of 220b
NP_956276.2
1680 aa
CG42672,  D.melanogaster
CG42672
NP_001137724.1
1476 aa
AgaP_AGAP012141,  A.gambiae
AgaP_AGAP012141
XP_320386.4
1424 aa
tag-144,  C.elegans
tag-144
NP_001040943.3
1433 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The ARMS/Kidins220 scaffold protein modulates synaptic transmission.
Arévalo JC, et al. Mol Cell Neurosci 45, 92-100 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
Ank_5 (pfam13857)
  Ankyrin repeats (many copies).
KAP_NTPase (pfam07693)
  KAP family P-loop domain.
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
SAM_superfamily (cl15755)
  SAM (Sterile alpha motif ).
Ank_5 (cl02529)
  Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
SAM_superfamily (cl15755)
  SAM (Sterile alpha motif ).
AAA (cl18944)
  The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Kidins220 includes H.sapiens KIDINS220 and R.norvegicus Kidins220.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (20 transcripts, 9 species)
Mammalia - mammals (18 transcripts, 15 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (7 transcripts, 6 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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