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HomoloGene:20911. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

BMPR1A,  H.sapiens
bone morphogenetic protein receptor, type IA
NP_004320.2
532 aa
BMPR1A,  P.troglodytes
bone morphogenetic protein receptor, type IA
XP_507889.2
532 aa
BMPR1A,  M.mulatta
bone morphogenetic protein receptor, type IA
XP_002805693.1
532 aa
BMPR1A,  C.lupus
bone morphogenetic protein receptor, type IA
NP_001138622.1
532 aa
BMPR1A,  B.taurus
bone morphogenetic protein receptor, type IA
NP_001070268.1
532 aa
Bmpr1a,  M.musculus
bone morphogenetic protein receptor, type 1A
NP_033888.2
532 aa
Bmpr1a,  R.norvegicus
bone morphogenetic protein receptor, type IA
NP_110476.1
532 aa
BMPR1A,  G.gallus
bone morphogenetic protein receptor, type IA
NP_990688.1
533 aa
bmpr1a,  X.tropicalis
bone morphogenetic protein receptor, type 1A
XP_002937617.2
653 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cowden-like syndrome.
Juvenile polyposis syndrome, infantile form.
Polyposis, juvenile intestinal.
Polyposis syndrome, hereditary mixed, 2.



Publications
Articles associated with genes and sequences of this homology group.

BMPR1A mutations in juvenile polyposis affect cellular localization.
Howe JR, et al. J Surg Res 184, 739-45 (2013).
A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength.
Baud'huin M, et al. Proc Natl Acad Sci U S A 109, 12207-12 (2012).
Promiscuity and specificity in BMP receptor activation.
Mueller TD & Nickel J. FEBS Lett 586, 1846-59 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Pkinase (pfam00069)
  Protein kinase domain.
Activin_recp (pfam01064)
  Activin types I and II receptor domain.
ARA70 (pfam12489)
  Nuclear coactivator.
TGF_beta_GS (cl02621)
  Transforming growth factor beta type I GS-motif.
Pkinase (pfam00069)
  Protein kinase domain.
Activin_recp (pfam01064)
  Activin types I and II receptor domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Bmpr1a includes H.sapiens BMPR1A and R.norvegicus Bmpr1a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 9 species)
Actinopterygii - bony fishes (10 transcripts, 7 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 9 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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