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HomoloGene:37766. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

XPNPEP2,  H.sapiens
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
NP_003390.4
674 aa
XPNPEP2,  P.troglodytes
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
XP_521256.3
644 aa
XPNPEP2,  M.mulatta
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
XP_001091201.1
674 aa
XPNPEP2,  C.lupus
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
XP_549245.3
677 aa
XPNPEP2,  B.taurus
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
NP_001192484.1
673 aa
Xpnpep2,  M.musculus
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
NP_573476.2
674 aa
Xpnpep2,  R.norvegicus
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
NP_476496.1
674 aa
XPNPEP2,  G.gallus
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
XP_420139.4
738 aa
xpnpep2,  X.tropicalis
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
XP_002940335.2
673 aa
xpnpep2,  D.rerio
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
NP_957326.1
702 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Angioedema induced by ACE inhibitors, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

The cloning and functional expression of human pancreatic aminopeptidase P.
Cottrell GS, et al. Biochem Soc Trans 26, S248 (1998).
Cloning and tissue distribution of human membrane-bound aminopeptidase P.
Venema RC, et al. Biochim Biophys Acta 1354, 45-8 (1997).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Creatinase_N (pfam01321)
  Creatinase/Prolidase N-terminal domain.
Creatinase_N (pfam01321)
  Creatinase/Prolidase N-terminal domain.
APP_MetAP (cl00279)
  A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Xpnpep2 includes H.sapiens XPNPEP2 and R.norvegicus Xpnpep2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (8 transcripts, 8 species)
Mammalia - mammals (7 transcripts, 7 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

 

 

 

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