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HomoloGene:3959. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

TP53BP2,  H.sapiens
tumor protein p53 binding protein, 2
1134 aa
TP53BP2,  P.troglodytes
tumor protein p53 binding protein, 2
1085 aa
TP53BP2,  M.mulatta
tumor protein p53 binding protein, 2
1134 aa
TP53BP2,  C.lupus
tumor protein p53 binding protein, 2
1124 aa
TP53BP2,  B.taurus
tumor protein p53 binding protein, 2
1126 aa
Trp53bp2,  M.musculus
transformation related protein 53 binding protein 2
1134 aa
Tp53bp2,  R.norvegicus
tumor protein p53 binding protein, 2
1128 aa
TP53BP2,  G.gallus
tumor protein p53 binding protein, 2
1146 aa
tp53bp2,  X.tropicalis
tumor protein p53 binding protein, 2
1101 aa
tp53bp2,  D.rerio
tumor protein p53 binding protein, 2
1060 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

The structure and interactions of the proline-rich domain of ASPP2.
Rotem S, et al. J Biol Chem 283, 18990-9 (2008).
TP53BP2 locus is associated with gastric cancer susceptibility.
Ju H, et al. Int J Cancer 117, 957-60 (2005).
Apoptosis-stimulating protein of p53-2 (ASPP2/53BP2L) is an E2F target gene.
Chen D, et al. Cell Death Differ 12, 358-68 (2005).
Expression of 53BP2 and ASPP2 proteins from TP53BP2 gene by alternative splicing.
Takahashi N, et al. Biochem Biophys Res Commun 315, 434-8 (2004).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
Ank_4 (pfam13637)
  Ankyrin repeats (many copies).
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
UBQ (cl00155)
  Ubiquitin-like proteins.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
UBQ (cl00155)
  Ubiquitin-like proteins.
BAR (cl12013)
  The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Trp53bp2 includes H.sapiens TP53BP2 and R.norvegicus Tp53bp2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (19 transcripts, 13 species)
Actinopterygii - bony fishes (13 transcripts, 8 species)
Aves - birds (5 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)

Insecta - insects (1 transcript, 1 species)

Hydrozoa - hydrozoans (1 transcript, 1 species)




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