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HomoloGene:400. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

BARD1,  H.sapiens
BRCA1 associated RING domain 1
777 aa
BARD1,  P.troglodytes
BRCA1 associated RING domain 1
777 aa
BARD1,  M.mulatta
BRCA1 associated RING domain 1
777 aa
BARD1,  C.lupus
BRCA1 associated RING domain 1
922 aa
BARD1,  B.taurus
BRCA1 associated RING domain 1
772 aa
Bard1,  M.musculus
BRCA1 associated RING domain 1
765 aa
Bard1,  R.norvegicus
BRCA1 associated RING domain 1
768 aa
BARD1,  G.gallus
BRCA1 associated RING domain 1
750 aa
bard1,  X.tropicalis
BRCA1 associated RING domain 1
757 aa
LOC100147913,  D.rerio
novel protein similar to vertebrate BRCA1 associated RING domain 1 (BARD1)
653 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Breast cancer, susceptibility to.

Articles associated with genes and sequences of this homology group.

Replication of neuroblastoma SNP association at the BARD1 locus in African-Americans.
Latorre V, et al. Cancer Epidemiol Biomarkers Prev 21, 658-63 (2012).
BARD1 expression predicts outcome in colon cancer.
Sporn JC, et al. Clin Cancer Res 17, 5451-62 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
BRCT (cl00038)
  Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks.
RING (cl17238)
  RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Bard1 includes H.sapiens BARD1 and R.norvegicus Bard1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (9 transcripts, 9 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Actinopterygii - bony fishes (1 transcript, 1 species)

Insecta - insects (2 transcripts, 2 species)




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