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HomoloGene:4349. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MTHFR,  H.sapiens
methylenetetrahydrofolate reductase (NAD(P)H)
NP_005948.3
656 aa
MTHFR,  P.troglodytes
methylenetetrahydrofolate reductase (NAD(P)H)
XP_001141040.1
656 aa
LOC714840,  M.mulatta
methylenetetrahydrofolate reductase-like
XP_001105017.1
656 aa
MTHFR,  C.lupus
methylenetetrahydrofolate reductase (NAD(P)H)
XP_005618049.1
697 aa
MTHFR,  B.taurus
methylenetetrahydrofolate reductase (NAD(P)H)
NP_001011685.1
655 aa
Mthfr,  M.musculus
5,10-methylenetetrahydrofolate reductase
NP_001155270.1
695 aa
Mthfr,  R.norvegicus
methylenetetrahydrofolate reductase (NAD(P)H)
XP_342976.3
695 aa
MTHFR,  G.gallus
methylenetetrahydrofolate reductase (NAD(P)H)
XP_417645.3
651 aa
mthfr,  X.tropicalis
methylenetetrahydrofolate reductase (NAD(P)H)
NP_001096464.1
643 aa
mthfr,  D.rerio
methylenetetrahydrofolate reductase (NAD(P)H)
NP_001121727.1
656 aa
mthf-1,  C.elegans
mthf-1
NP_741028.1
642 aa
MET13,  S.cerevisiae
MET13
NP_011390.2
600 aa
KLLA0F09647g,  K.lactis
KLLA0F09647g
XP_455518.1
604 aa
AGOS_AAR170W,  E.gossypii
AGOS_AAR170W
NP_982713.2
603 aa
met9,  S.pombe
met9
NP_593224.1
603 aa
MGG_01728,  M.oryzae
MGG_01728
XP_003714725.1
631 aa
NCU07690,  N.crassa
NCU07690
XP_961729.1
613 aa
MTHFR2,  A.thaliana
MTHFR2
NP_566011.1
594 aa
MTHFR1,  A.thaliana
MTHFR1
NP_191556.1
592 aa
Os03g0815200,  O.sativa
Os03g0815200
NP_001051683.1
594 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Homocystinuria due to MTHFR deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Mthfr gene ablation enhances susceptibility to arsenic prenatal toxicity.
Wlodarczyk BJ, et al. Toxicol Appl Pharmacol 275, 22-7 (2014).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MTHFR (cl00246)
  Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase to convert homocysteine to methionine. The enzymatic mechanism is a ping-pong bi-bi mechanism, in which NAD(P)+ release precedes the binding of methylenetetrahydrofolate and the acceptor is free FAD. The family includes the 5,10-methylenetetrahydrofolate reductase EC:1.7.99.5 from prokaryotes and methylenetetrahydrofolate reductase EC: 1.5.1.20 from eukaryotes. The bacterial enzyme is a homotetramer and NADH is the preferred reductant while the eukaryotic enzyme is a homodimer and NADPH is the preferred reductant. In humans, there are several clinically significant mutations in MTHFR that result in hyperhomocysteinemia, which is a risk factor for the development of cardiovascular disease.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mthfr includes H.sapiens MTHFR and R.norvegicus Mthfr.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (59 transcripts, 34 species)
Liliopsida - monocots (10 transcripts, 9 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chordata
Mammalia - mammals (9 transcripts, 9 species)
Actinopterygii - bony fishes (9 transcripts, 8 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (3 transcripts, 3 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (5 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (2 transcripts, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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