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HomoloGene:1241. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

APEX1,  H.sapiens
APEX nuclease (multifunctional DNA repair enzyme) 1
NP_001231178.1
318 aa
APEX1,  P.troglodytes
APEX nuclease (multifunctional DNA repair enzyme) 1
NP_001074954.1
318 aa
APEX1,  M.mulatta
APEX nuclease (multifunctional DNA repair enzyme) 1
XP_001090240.1
318 aa
APEX1,  C.lupus
APEX nuclease (multifunctional DNA repair enzyme) 1
NP_001138591.1
318 aa
APEX1,  B.taurus
APEX nuclease (multifunctional DNA repair enzyme) 1
NP_788782.2
318 aa
Apex1,  M.musculus
apurinic/apyrimidinic endonuclease 1
NP_033817.1
317 aa
Apex1,  R.norvegicus
APEX nuclease (multifunctional DNA repair enzyme) 1
NP_077062.1
317 aa
APEX1,  G.gallus
APEX nuclease (multifunctional DNA repair enzyme) 1
NP_001171688.1
300 aa
apex1,  X.tropicalis
APEX nuclease (multifunctional DNA repair enzyme) 1
NP_989307.1
316 aa
apex1,  D.rerio
APEX nuclease (multifunctional DNA repair enzyme) 1
NP_998586.1
310 aa
AgaP_AGAP009587,  A.gambiae
AgaP_AGAP009587
XP_318609.4
606 aa
ARP,  A.thaliana
ARP
NP_181677.1
536 aa
Os01g0801000,  O.sativa
Os01g0801000
NP_001044537.1
499 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Genetic variant in APE1 gene promoter contributes to cervical cancer risk.
Wang M, et al. Am J Obstet Gynecol 209, 360.e1-7 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SAP (pfam02037)
  SAP domain.
EEP (cl00490)
  Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily.
SAP (cl02640)
  The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Apex1 includes H.sapiens APEX1 and R.norvegicus Apex1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 16 species)
Actinopterygii - bony fishes (12 transcripts, 11 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (12 transcripts, 8 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (14 transcripts, 14 species)
Liliopsida - monocots (14 transcripts, 9 species)
Coniferopsida - conifers (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (3 transcripts, 2 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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