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HomoloGene:7257. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

CBX5,  H.sapiens
chromobox homolog 5
191 aa
CBX5,  P.troglodytes
chromobox homolog 5
191 aa
CBX5,  M.mulatta
chromobox homolog 5
191 aa
CBX5,  C.lupus
chromobox homolog 5
191 aa
CBX5,  B.taurus
chromobox homolog 5
191 aa
Cbx5,  M.musculus
chromobox 5
191 aa
Cbx5,  R.norvegicus
chromobox homolog 5
191 aa
cbx5,  X.tropicalis
chromobox homolog 5
200 aa
cbx5,  D.rerio
chromobox homolog 5 (HP1 alpha homolog, Drosophila)
204 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Epigenetic aspects of HP1 exchange kinetics in apoptotic chromatin.
Legartová S, et al. Biochimie 95, 167-79 (2013).
Tuning HP1α chromodomain selectivity for di- and trimethyllysine.
Eisert RJ & Waters ML. Chembiochem 12, 2786-90 (2011).
Analysis of HP1α regulation in human breast cancer cells.
Thomsen R, et al. Mol Carcinog 50, 601-13 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Chromo_shadow (pfam01393)
  Chromo shadow domain.
ChSh (cl00044)
  Chromo Shadow Domain, found in association with N-terminal chromo (CHRromatin Organization MOdifier) domain; Chromo domains mediate the interaction of the heterochromatin with other heterochromatin proteins, thereby affecting chromatin structure (e.g. ...
CHROMO (cl17459)
  Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence implicates the chromo domain in the binding activity of these proteins to methylated histone tails and maybe RNA. May occur as single instance, in a tandem arrangement or followd by a related "chromo shadow" domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cbx5 includes H.sapiens CBX5 and R.norvegicus Cbx5.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (14 transcripts, 12 species)
Actinopterygii - bony fishes (9 transcripts, 9 species)
Amniota - vertebrates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Insecta - insects (13 transcripts, 12 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Trematoda - flatworms (2 transcripts, 2 species)

Hydrozoa - hydrozoans (1 transcript, 1 species)




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