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HomoloGene:18868. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TMEM173,  H.sapiens
transmembrane protein 173
NP_938023.1
379 aa
TMEM173,  P.troglodytes
transmembrane protein 173
XP_001135484.1
379 aa
TMEM173,  M.mulatta
transmembrane protein 173
XP_001084548.1
379 aa
TMEM173,  C.lupus
transmembrane protein 173
XP_005617314.1
375 aa
TMEM173,  B.taurus
transmembrane protein 173
NP_001039822.1
378 aa
Tmem173,  M.musculus
transmembrane protein 173
NP_082537.1
378 aa
Tmem173,  R.norvegicus
transmembrane protein 173
NP_001102592.1
379 aa
TMEM173,  G.gallus
transmembrane protein 173
XP_001232171.2
379 aa
tmem173,  X.tropicalis
transmembrane protein 173
NP_001106445.2
355 aa
tmem173,  D.rerio
transmembrane protein 173
NP_001265766.1
398 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The cGAS-STING pathway for DNA sensing.
Xiao TS & Fitzgerald KA. Mol Cell 51, 135-9 (2013).
Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING.
Chin KH, et al. Acta Crystallogr D Biol Crystallogr 69, 352-66 (2013).
Crystallization studies of the murine c-di-GMP sensor protein STING.
Su YC, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun 68, 906-10 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
AFOR_C (pfam01314)
  Aldehyde ferredoxin oxidoreductase, domains 2 & 3.
STING_C (cl17092)
  STING (stimulator of interferon genes, also known as MITA, ERIS, MPYS and TMEM173) is a master regulator that mediates cytokine production in response to microbial invasion by directly sensing bacterial secondary messengers such as the cyclic dinucleotide bis-(3'-5')-cyclic dimeric GMP (c-di-GMP) and leading to the activation of IFN regulatory factor 3 (IRF3) through TANK-binding kinase 1 (TBK1) stimulation. STING is also a signaling adaptor in the IFN response to cytosolic DNA. This detection of foreign materials is the first step to a successful immune responses. STING is localized in the ER and comprised of an predicted N-terminal transmembrane region and a C-terminal c-di-GMP binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tmem173 includes H.sapiens TMEM173.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 8 species)

 

 

 

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