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HomoloGene:1814. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MKI67,  H.sapiens
marker of proliferation Ki-67
NP_002408.3
3256 aa
MKI67,  P.troglodytes
antigen identified by monoclonal antibody Ki-67
XP_508147.2
3257 aa
MKI67,  M.mulatta
antigen identified by monoclonal antibody Ki-67
XP_001089669.2
3120 aa
MKI67,  C.lupus
antigen identified by monoclonal antibody Ki-67
XP_005637950.1
1682 aa
MKI67,  B.taurus
antigen identified by monoclonal antibody Ki-67
XP_005225930.1
3353 aa
Mki67,  M.musculus
antigen identified by monoclonal antibody Ki 67
NP_001074586.2
3177 aa
Mki67,  R.norvegicus
marker of proliferation Ki-67
NP_001258295.1
3119 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

An integrated framework for automatic Ki-67 scoring in pancreatic neuroendocrine tumor.
Xing F, et al. Med Image Comput Comput Assist Interv 16, 436-43 (2013).
Ki67 measured after neoadjuvant chemotherapy for primary breast cancer.
von Minckwitz G, et al. Clin Cancer Res 19, 4521-31 (2013).
Increased Ki-67 immunoreactivity in the white matter in hemimegalencephaly.
Munakata M, et al. Neurosci Lett 548, 244-8 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
K167R (pfam08065)
  K167R (NUC007) repeat.
PP1_bind (pfam15276)
  Protein phosphatase 1 binding.
FHA (cl00062)
  Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mki67 includes H.sapiens MKI67 and R.norvegicus Mki67.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (5 transcripts, 4 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

 

 

 

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