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HomoloGene:5719. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

NCS1,  H.sapiens
neuronal calcium sensor 1
NP_055101.2
190 aa
NCS1,  C.lupus
neuronal calcium sensor 1
XP_005625293.1
194 aa
NCS1,  B.taurus
neuronal calcium sensor 1
XP_005213538.1
512 aa
Ncs1,  M.musculus
neuronal calcium sensor 1
NP_062655.1
190 aa
Ncs1,  R.norvegicus
neuronal calcium sensor 1
NP_077342.1
190 aa
NCS1,  G.gallus
neuronal calcium sensor 1
NP_990708.1
190 aa
ncs1,  X.tropicalis
neuronal calcium sensor 1
NP_988973.1
190 aa
ncs1b,  D.rerio
neuronal calcium sensor 1b
NP_001018350.1
190 aa
Frq1,  D.melanogaster
Frequenin 1
NP_573271.1
187 aa
Frq2,  D.melanogaster
Frequenin 2
NP_001259675.1
187 aa
AgaP_AGAP013126,  A.gambiae
AgaP_AGAP013126
XP_003437186.1
111 aa
ncs-1,  C.elegans
ncs-1
NP_508186.1
191 aa
FRQ1,  S.cerevisiae
FRQ1
NP_010661.3
190 aa
KLLA0E02399g,  K.lactis
KLLA0E02399g
XP_454056.1
190 aa
AGOS_ACL163W,  E.gossypii
AGOS_ACL163W
NP_983241.1
190 aa
ncs1,  S.pombe
ncs1
NP_592879.1
190 aa
MGG_01550,  M.oryzae
MGG_01550
XP_003714524.1
190 aa
NCU04379,  N.crassa
NCU04379
XP_957456.1
190 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Multiple roles for frequenin/NCS-1 in synaptic function and development.
Dason JS, et al. Mol Neurobiol 45, 388-402 (2012).
Modulation of muscarinic signaling in PC12 cells overexpressing neuronal Ca2+ sensor-1 protein.
Guimarães MM, et al. Cell Mol Biol (Noisy-le-grand) 55 Suppl, OL1138-50 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
EF_hand_6 (pfam13833)
  EF-hand domain pair.
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
EF-hand_8 (cl17302)
  EF-hand domain pair.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ncs1 includes H.sapiens NCS1.

 

 

 

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