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HomoloGene:55534. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

GNAS,  H.sapiens
GNAS complex locus
NP_536350.2
1037 aa
GNAS,  P.troglodytes
GNAS complex locus
XP_001138016.3
431 aa
GNAS,  M.mulatta
GNAS complex locus
XP_001083687.2
1046 aa
GNAS,  C.lupus
GNAS complex locus
NP_001003263.1
394 aa
GNAS,  B.taurus
GNAS complex locus
NP_851364.1
394 aa
Gnas,  M.musculus
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
NP_034439.2
1133 aa
Gnas,  R.norvegicus
GNAS complex locus
NP_068617.6
1144 aa
GNAS,  G.gallus
GNAS complex locus
XP_417485.3
320 aa
gnas,  X.tropicalis
GNAS complex locus
NP_998855.1
379 aa
gnas,  D.rerio
GNAS complex locus
XP_005172181.1
379 aa
G-salpha60A,  D.melanogaster
G protein salpha 60A
NP_726388.1
382 aa
GNAS_ANOGA,  A.gambiae
GNAS_ANOGA
XP_320433.1
383 aa
gsa-1,  C.elegans
gsa-1
NP_490817.3
375 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Acromegaly.
Pseudohypoparathyroidism, type Ia.
Pituitary ACTH secreting adenoma.
Prolonged bleeding time, brachydactyly and mental retardation.
Somatotrophinoma.
Osseous heteroplasia, progressive.
McCune-Albright syndrome.
Pseudohypoparathyroidism, type Ib.



Publications
Articles associated with genes and sequences of this homology group.

Endocrine profile and phenotype-(epi)genotype correlation in Spanish patients with pseudohypoparathyroidism.
Fernández-Rebollo E, et al. J Clin Endocrinol Metab 98, E996-1006 (2013).
Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms.
Nishikawa G, et al. Br J Cancer 108, 951-8 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gnas includes H.sapiens GNAS and R.norvegicus Gnas.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 14 species)
Actinopterygii - bony fishes (11 transcripts, 7 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)

Arthropoda
Insecta - insects (15 transcripts, 10 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (4 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (3 transcripts, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

 

 

 

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