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HomoloGene:8588. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ITPK1,  H.sapiens
inositol-tetrakisphosphate 1-kinase
NP_001136065.1
414 aa
ITPK1,  P.troglodytes
inositol-tetrakisphosphate 1-kinase
XP_003314550.1
432 aa
ITPK1,  M.mulatta
inositol-tetrakisphosphate 1-kinase
XP_001094303.1
414 aa
ITPK1,  C.lupus
inositol-tetrakisphosphate 1-kinase
XP_547713.2
419 aa
ITPK1,  B.taurus
inositol-tetrakisphosphate 1-kinase
NP_001179418.1
419 aa
Itpk1,  M.musculus
inositol 1,3,4-triphosphate 5/6 kinase
NP_766172.1
419 aa
Itpk1,  R.norvegicus
inositol-tetrakisphosphate 1-kinase
NP_001178914.1
421 aa
ITPK1,  G.gallus
inositol-tetrakisphosphate 1-kinase
NP_001012606.1
407 aa
itpk1,  X.tropicalis
inositol-tetrakisphosphate 1-kinase
NP_001017136.1
320 aa
LOC100148744,  D.rerio
inositol-tetrakisphosphate 1-kinase-like
XP_001922368.1
401 aa
AT4G33770,  A.thaliana
AT4G33770
NP_195103.3
391 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Neural tube defects in mice with reduced levels of inositol 1,3,4-trisphosphate 5/6-kinase.
Wilson MP, et al. Proc Natl Acad Sci U S A 106, 9831-5 (2009).
Integration of inositol phosphate signaling pathways via human ITPK1.
Chamberlain PP, et al. J Biol Chem 282, 28117-25 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ins134_P3_kin (pfam05770)
  Inositol 1, 3, 4-trisphosphate 5/6-kinase.
ATP-grasp_4 (cl17255)
  ATP-grasp domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Itpk1 includes H.sapiens ITPK1 and R.norvegicus Itpk1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (10 transcripts, 5 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 5 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (13 transcripts, 8 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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