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HomoloGene:22628. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CYFIP1,  H.sapiens
cytoplasmic FMR1 interacting protein 1
NP_055423.1
1253 aa
CYFIP1,  P.troglodytes
cytoplasmic FMR1 interacting protein 1
XP_003314612.1
1253 aa
CYFIP1,  M.mulatta
cytoplasmic FMR1 interacting protein 1
XP_002804722.1
1248 aa
CYFIP1,  B.taurus
cytoplasmic FMR1 interacting protein 1
NP_001192444.1
1253 aa
Cyfip1,  M.musculus
cytoplasmic FMR1 interacting protein 1
NP_035500.2
1253 aa
Cyfip1,  R.norvegicus
cytoplasmic FMR1 interacting protein 1
NP_001100987.1
1253 aa
CYFIP1,  G.gallus
cytoplasmic FMR1 interacting protein 1
XP_003640571.1
1253 aa
cyfip1,  X.tropicalis
cytoplasmic FMR1 interacting protein 1
XP_004911869.1
1253 aa
cyfip1,  D.rerio
cytoplasmic FMR1 interacting protein 1
NP_997924.1
1253 aa
gex-2,  C.elegans
gex-2
NP_499949.2
1262 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Cyfip1 is a putative invasion suppressor in epithelial cancers.
Silva JM, et al. Cell 137, 1047-61 (2009).
A co-segregating microduplication of chromosome 15q11.2 pinpoints two risk genes for autism spectrum disorder.
van der Zwaag B, et al. Am J Med Genet B Neuropsychiatr Genet 153B, 960-6 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF1394 (pfam07159)
  Protein of unknown function (DUF1394).
FragX_IP (pfam05994)
  Cytoplasmic Fragile-X interacting family.
FragX_IP (pfam05994)
  Cytoplasmic Fragile-X interacting family.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cyfip1 includes H.sapiens CYFIP1 and R.norvegicus Cyfip1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (24 transcripts, 10 species)
Mammalia - mammals (22 transcripts, 14 species)
Aves - birds (4 transcripts, 2 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Porifera
Demospongiae - sponges (3 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

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