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HomoloGene:41274. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

HDAC8,  H.sapiens
histone deacetylase 8
NP_060956.1
377 aa
HDAC8,  P.troglodytes
histone deacetylase 8-like
XP_003317568.1
196 aa
LOC699642,  M.mulatta
histone deacetylase 8-like
XP_001093861.2
415 aa
HDAC8,  C.lupus
histone deacetylase 8
XP_005641547.1
451 aa
HDAC8,  B.taurus
histone deacetylase 8
NP_001069699.1
377 aa
Hdac8,  M.musculus
histone deacetylase 8
NP_081658.1
377 aa
Hdac8,  R.norvegicus
histone deacetylase 8
NP_001119845.2
377 aa
LOC100911968,  R.norvegicus
histone deacetylase 8-like
XP_003752118.1
377 aa
HDAC8,  G.gallus
histone deacetylase 8
XP_420178.1
368 aa
hdac8,  X.tropicalis
histone deacetylase 8
NP_001120462.1
369 aa
hdac8,  D.rerio
histone deacetylase 8
NP_998596.1
378 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Activation and inhibition of histone deacetylase 8 by monovalent cations.
Gantt SL, et al. J Biol Chem 285, 6036-43 (2010).
Histone deacetylase 8 in neuroblastoma tumorigenesis.
Oehme I, et al. Clin Cancer Res 15, 91-9 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Arginase_HDAC (cl17011)
  Arginase-like and histone-like hydrolases.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hdac8 includes H.sapiens HDAC8 and R.norvegicus Hdac8.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 8 species)
Actinopterygii - bony fishes (6 transcripts, 6 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 4 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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