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HomoloGene:5171. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ZIC2,  H.sapiens
Zic family member 2
NP_009060.2
532 aa
ZIC2,  P.troglodytes
Zic family member 2
XP_003314245.1
533 aa
ZIC2,  M.mulatta
Zic family member 2
XP_001093759.2
530 aa
ZIC2,  C.lupus
Zic family member 2
XP_542652.2
472 aa
ZIC2,  B.taurus
Zic family member 2
NP_001193295.1
525 aa
Zic2,  M.musculus
zinc finger protein of the cerebellum 2
NP_033600.3
529 aa
Zic2,  R.norvegicus
Zic family member 2
NP_001101862.2
529 aa
ZIC2,  G.gallus
Zic family member 2
XP_003640593.2
347 aa
zic2,  X.tropicalis
Zic family member 2
NP_001017025.2
501 aa
zic2a,  D.rerio
zic family member 2 (odd-paired homolog, Drosophila), a
NP_571633.1
445 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Holoprosencephaly-5.



Publications
Articles associated with genes and sequences of this homology group.

Transcription factor Zic2 inhibits Wnt/β-catenin protein signaling.
Pourebrahim R, et al. J Biol Chem 286, 37732-40 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
zf-H2C2_2 (pfam13465)
  Zinc-finger double domain.
COG5048 (COG5048)
  FOG: Zn-finger [General function prediction only].
zf-C2H2 (cl15478)
  Zinc finger, C2H2 type.
zf-H2C2_2 (cl19539)
  Zinc-finger double domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Zic2 includes H.sapiens ZIC2 and R.norvegicus Zic2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (10 transcripts, 7 species)
Mammalia - mammals (8 transcripts, 6 species)
Amphibia - amphibians (3 transcripts, 2 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

 

 

 

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