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HomoloGene:113729. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ATP1A3,  H.sapiens
ATPase, Na+/K+ transporting, alpha 3 polypeptide
NP_001243143.1
1026 aa
ATP1A3,  P.troglodytes
ATPase, Na+/K+ transporting, alpha 3 polypeptide
XP_003316427.1
1088 aa
ATP1A3,  M.mulatta
ATPase, Na+/K+ transporting, alpha 3 polypeptide
XP_002801302.1
1026 aa
ATP1A3,  C.lupus
ATPase, Na+/K+ transporting, alpha 3 polypeptide
XP_005616573.1
1027 aa
ATP1A3,  B.taurus
ATPase, Na+/K+ transporting, alpha 3 polypeptide
XP_002695120.2
988 aa
Atp1a3,  M.musculus
ATPase, Na+/K+ transporting, alpha 3 polypeptide
NP_659170.1
1053 aa
Atp1a3,  R.norvegicus
ATPase, Na+/K+ transporting, alpha 3 polypeptide
NP_036638.1
1013 aa
ATP1A3,  G.gallus
ATPase, Na+/K+ transporting, alpha 3 polypeptide
NP_990806.1
1010 aa
atp1a3,  X.tropicalis
ATPase, Na+/K+ transporting, alpha 3 polypeptide
NP_001120366.1
1025 aa
atp1a3a,  D.rerio
ATPase, Na+/K+ transporting, alpha 3a polypeptide
NP_571759.2
1023 aa
atp1a3b,  D.rerio
ATPase, Na+/K+ transporting, alpha 3b polypeptide
NP_571760.2
1023 aa
Atpalpha,  D.melanogaster
Na pump alpha subunit
NP_732572.1
1041 aa
AgaP_AGAP002858,  A.gambiae
AgaP_AGAP002858
XP_003436267.1
1040 aa
eat-6,  C.elegans
eat-6
NP_506269.1
996 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Flies heterozygous for Hypomorphic mutant alleles show a bang-sensitive phenotype and are lethargic. Haplo-insufficient - flies heterozygous for a complete deletion are sluggish and less tolerant of physical stress than normal.

H.sapiens
Dystonia-12.



Publications
Articles associated with genes and sequences of this homology group.

De novo mutations in ATP1A3 cause alternating hemiplegia of childhood.
Heinzen EL, et al. Nat Genet 44, 1030-4 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HAD_like (cd01427)
  Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
HAD_like (cl11391)
  Haloacid Dehalogenase-like Hydrolases.
HAD_like (cl11391)
  Haloacid Dehalogenase-like Hydrolases.
E1-E2_ATPase (pfam00122)
  E1-E2 ATPase.
Cation_ATPase_C (pfam00689)
  Cation transporting ATPase, C-terminus.
Hydrolase_like2 (pfam13246)
  Putative hydrolase of sodium-potassium ATPase alpha subunit.
COG4087 (COG4087)
  Soluble P-type ATPase [General function prediction only].
Cation_ATPase_N (cl02930)
  Cation transporter/ATPase, N-terminus.
E1-E2_ATPase (pfam00122)
  E1-E2 ATPase.
Cation_ATPase_C (pfam00689)
  Cation transporting ATPase, C-terminus.
Hydrolase_like2 (pfam13246)
  Putative hydrolase of sodium-potassium ATPase alpha subunit.
Cation_ATPase_N (cl02930)
  Cation transporter/ATPase, N-terminus.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Atp1a3 includes H.sapiens ATP1A3 and R.norvegicus Atp1a3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (25 transcripts, 11 species)
Mammalia - mammals (15 transcripts, 10 species)
Amphibia - amphibians (5 transcripts, 2 species)
Aves - birds (4 transcripts, 2 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Cephalochordata - lancelets (3 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (17 transcripts, 11 species)
Malacostraca - crustaceans (3 transcripts, 1 species)
Arachnida - arachnids (2 transcripts, 2 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (5 transcripts, 2 species)
Turbellaria - flatworms (4 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (5 transcripts, 2 species)
Anthozoa - anthozoans (3 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (6 transcripts, 2 species)

Annelida
Hirudinida - segmented worms (4 transcripts, 1 species)
Polychaeta - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (4 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Dictyosteliida
Dictyostelium - cellular slime molds (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 1 species)

Streptophyta
Eudicotyledons - eudicots (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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