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HomoloGene:68054. Gene conserved in Eukaryota Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

CYBB,  H.sapiens
cytochrome b-245, beta polypeptide
570 aa
LOC465566,  P.troglodytes
cytochrome b-245 heavy chain-like
570 aa
CYBB,  M.mulatta
cytochrome b-245, beta polypeptide (chronic granulomatous disease)
570 aa
CYBB,  C.lupus
cytochrome b-245, beta polypeptide (chronic granulomatous disease)
570 aa
CYBB,  B.taurus
cytochrome b-245, beta polypeptide
570 aa
Cybb,  M.musculus
cytochrome b-245, beta polypeptide
570 aa
Cybb,  R.norvegicus
cytochrome b-245, beta polypeptide
570 aa
CYBB,  G.gallus
cytochrome b-245, beta polypeptide
571 aa
cybb,  X.tropicalis
cytochrome b-245, beta polypeptide
570 aa
cybb,  D.rerio
cytochrome b-245, beta polypeptide (chronic granulomatous disease)
565 aa
MGG_06559,  M.oryzae
582 aa
NCU10775,  N.crassa
581 aa
AT1G19230,  A.thaliana
926 aa
Os09g0438000,  O.sativa
1007 aa
Os08g0453700,  O.sativa
1033 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Chronic granulomatous disease, X-linked.

Articles associated with genes and sequences of this homology group.

Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress.
Nazarewicz RR, et al. Am J Physiol Heart Circ Physiol 305, H1131-40 (2013).
Deficiency of gp91phox inhibits allergic airway inflammation.
Sevin CM, et al. Am J Respir Cell Mol Biol 49, 396-402 (2013).
X-ROS signalling is enhanced and graded by cyclic cardiomyocyte stretch.
Prosser BL, et al. Cardiovasc Res 98, 307-14 (2013).
Nitroxyl (HNO) suppresses vascular Nox2 oxidase activity.
Miller AA, et al. Free Radic Biol Med 60, 264-71 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NADPH_Ox (pfam08414)
  Respiratory burst NADPH oxidase.
Ferric_reduct (pfam01794)
  Ferric reductase like transmembrane component.
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NADPH_Ox (pfam08414)
  Respiratory burst NADPH oxidase.
EF-hand_7 (pfam13499)
  EF-hand domain pair.
Ferric_reduct (cl01043)
  This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.
FNR_like (cl06868)
  Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cybb includes H.sapiens CYBB and R.norvegicus Cybb.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (14 transcripts, 11 species)
Actinopterygii - bony fishes (11 transcripts, 9 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Echinoidea - sea urchins (2 transcripts, 2 species)

Demospongiae - sponges (1 transcript, 1 species)

Polychaeta - segmented worms (1 transcript, 1 species)

Liliopsida - monocots (17 transcripts, 8 species)
Eudicotyledons - eudicots (6 transcripts, 5 species)
Coniferopsida - conifers (1 transcript, 1 species)

Sordariomycetes - ascomycetes (6 transcripts, 2 species)
Eurotiomycetes - ascomycetes (2 transcripts, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Monosiga - choanoflagellates (1 transcript, 1 species)




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