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HomoloGene:6526. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

LARS2,  H.sapiens
leucyl-tRNA synthetase 2, mitochondrial
NP_056155.1
903 aa
LARS2,  P.troglodytes
leucyl-tRNA synthetase 2, mitochondrial
XP_001147749.1
903 aa
LARS2,  M.mulatta
leucyl-tRNA synthetase 2, mitochondrial
XP_001114552.2
922 aa
LARS2,  C.lupus
leucyl-tRNA synthetase 2, mitochondrial
XP_005632695.1
903 aa
Lars2,  M.musculus
leucyl-tRNA synthetase, mitochondrial
NP_694808.1
902 aa
Lars2,  R.norvegicus
leucyl-tRNA synthetase 2, mitochondrial
NP_001102257.1
714 aa
LARS2,  G.gallus
leucyl-tRNA synthetase 2, mitochondrial
XP_004939517.1
997 aa
lars2,  X.tropicalis
leucyl-tRNA synthetase 2, mitochondrial
XP_002938354.2
900 aa
lars2,  D.rerio
leucyl-tRNA synthetase 2, mitochondrial
NP_001099171.1
891 aa
Aats-leu,  D.melanogaster
Leucyl-tRNA synthetase
NP_647932.1
869 aa
AgaP_AGAP002014,  A.gambiae
AgaP_AGAP002014
XP_321043.4
860 aa
lars-2,  C.elegans
lars-2
NP_001021875.1
859 aa
NAM2,  S.cerevisiae
NAM2
NP_013486.3
894 aa
KLLA0E05325g,  K.lactis
KLLA0E05325g
XP_454185.1
875 aa
AGOS_AER043C,  E.gossypii
AGOS_AER043C
NP_984903.1
873 aa
SPAC4G8.09,  S.pombe
SPAC4G8.09
NP_593069.1
874 aa
MGG_04042,  M.oryzae
MGG_04042
XP_003719800.1
973 aa
NCU03814,  N.crassa
NCU03814
XP_961203.1
994 aa
EMB2369,  A.thaliana
EMB2369
NP_192344.1
973 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

Genetic association analysis of LARS2 with type 2 diabetes.
Reiling E, et al. Diabetologia 53, 103-10 (2010).
A novel noncoding RNA rescues mutant SOD1-mediated cell death.
Chang Y, et al. FASEB J 22, 691-702 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
tRNA-synt_1_2 (pfam13603)
  Leucyl-tRNA synthetase, Domain 2.
nt_trans (cl00015)
  nucleotidyl transferase superfamily.
Anticodon_Ia_like (cl12020)
  Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains.
tRNA-synt_1_2 (pfam13603)
  Leucyl-tRNA synthetase, Domain 2.
nt_trans (cl00015)
  nucleotidyl transferase superfamily.
Anticodon_Ia_like (cl12020)
  Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lars2 includes H.sapiens LARS2 and R.norvegicus Lars2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 9 species)
Actinopterygii - bony fishes (9 transcripts, 7 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 8 species)
Arachnida - arachnids (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (23 transcripts, 15 species)
Liliopsida - monocots (12 transcripts, 9 species)
Coniferopsida - conifers (2 transcripts, 2 species)
Bryopsida - mosses (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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