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HomoloGene:4453. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SPON1,  H.sapiens
spondin 1, extracellular matrix protein
NP_006099.2
807 aa
SPON1,  P.troglodytes
spondin 1, extracellular matrix protein
XP_508295.3
934 aa
SPON1,  M.mulatta
spondin 1, extracellular matrix protein
XP_001093336.1
807 aa
SPON1,  C.lupus
spondin 1, extracellular matrix protein
XP_534067.2
807 aa
SPON1,  B.taurus
spondin 1, extracellular matrix protein
NP_777168.1
807 aa
Spon1,  M.musculus
spondin 1, (f-spondin) extracellular matrix protein
NP_663559.1
807 aa
Spon1,  R.norvegicus
spondin 1, extracellular matrix protein
NP_742064.1
807 aa
SPON1,  G.gallus
spondin 1, extracellular matrix protein
NP_990182.1
802 aa
spon1,  X.tropicalis
spondin 1, extracellular matrix protein
NP_001090741.1
803 aa
spon1a,  D.rerio
spondin 1a
NP_571590.1
808 aa
CG17739,  D.melanogaster
CG17739
NP_610757.1
873 aa
AgaP_AGAP012307,  A.gambiae
AgaP_AGAP012307
XP_320234.3
860 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Effect of F-spondin on cementoblastic differentiation of human periodontal ligament cells.
Kitagawa M, et al. Biochem Biophys Res Commun 349, 1050-6 (2006).
VSGP/F-spondin: a new ovarian cancer marker.
Pyle-Chenault RA, et al. Tumour Biol 26, 245-57 (2005).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Reeler (cd08544)
  Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins.
Kunitz_BPTI (pfam00014)
  Kunitz/Bovine pancreatic trypsin inhibitor domain.
TSP_1 (pfam00090)
  Thrombospondin type 1 domain.
Spond_N (pfam06468)
  Spondin_N.
TSP_1 (cl15278)
  Thrombospondin type 1 domain.
Spond_N (pfam06468)
  Spondin_N.
KU (cl00101)
  BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
Reeler_cohesin_like (cl14606)
  Domains similar to the eukaryotic reeler domain and bacterial cohesins.
TSP_1 (cl15278)
  Thrombospondin type 1 domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Spon1 includes H.sapiens SPON1 and R.norvegicus Spon1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (12 transcripts, 8 species)
Mammalia - mammals (11 transcripts, 10 species)
Aves - birds (2 transcripts, 1 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (4 transcripts, 4 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

 

 

 

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