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HomoloGene:3034. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

FEN1,  H.sapiens
flap structure-specific endonuclease 1
NP_004102.1
380 aa
FEN1,  P.troglodytes
flap structure-specific endonuclease 1
XP_003951955.1
380 aa
FEN1,  M.mulatta
flap structure-specific endonuclease 1
XP_002799575.1
380 aa
FEN1,  C.lupus
flap structure-specific endonuclease 1
XP_005631709.1
380 aa
FEN1,  B.taurus
flap structure-specific endonuclease 1
NP_001030285.1
380 aa
Fen1,  M.musculus
flap structure specific endonuclease 1
NP_032025.2
380 aa
Fen1,  R.norvegicus
flap structure-specific endonuclease 1
NP_445882.1
380 aa
FEN1,  G.gallus
flap structure-specific endonuclease 1
NP_001072959.1
381 aa
fen1,  X.tropicalis
flap structure-specific endonuclease 1
NP_001017005.1
382 aa
fen1,  D.rerio
flap structure-specific endonuclease 1
NP_942115.1
330 aa
Fen1,  D.melanogaster
Flap endonuclease 1
NP_523765.1
385 aa
AgaP_AGAP011448,  A.gambiae
AgaP_AGAP011448
XP_317855.2
383 aa
crn-1,  C.elegans
crn-1
NP_491168.1
382 aa
RAD27,  S.cerevisiae
RAD27
NP_012809.1
382 aa
KLLA0F02992g,  K.lactis
KLLA0F02992g
XP_455215.1
381 aa
AGOS_ABL052C,  E.gossypii
AGOS_ABL052C
NP_982895.2
378 aa
rad2,  S.pombe
rad2
NP_594972.1
380 aa
MGG_03419,  M.oryzae
MGG_03419
XP_003716519.1
394 aa
NCU10776,  N.crassa
NCU10776
XP_001728355.1
396 aa
AT5G26680,  A.thaliana
AT5G26680
NP_001154740.1
383 aa
Os05g0540100,  O.sativa
Os05g0540100
NP_001056179.1
380 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Observation of unpaired substrate DNA in the flap endonuclease-1 active site.
Finger LD, et al. Nucleic Acids Res 41, 9839-47 (2013).
Structural basis of nuclear import of flap endonuclease 1 (FEN1).
de Barros AC, et al. Acta Crystallogr D Biol Crystallogr 68, 743-50 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PTZ00217 (PTZ00217)
  flap endonuclease-1; Provisional.
PIN_SF (cl14812)
  PIN (PilT N terminus) domain: Superfamily.
H3TH_StructSpec-5'-nucleases (cl14815)
  H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination.
PIN_SF (cl14812)
  PIN (PilT N terminus) domain: Superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fen1 includes H.sapiens FEN1 and R.norvegicus Fen1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 11 species)
Actinopterygii - bony fishes (13 transcripts, 9 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (11 transcripts, 10 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (27 transcripts, 25 species)
Liliopsida - monocots (15 transcripts, 8 species)
Coniferopsida - conifers (5 transcripts, 3 species)
Bryopsida - mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (5 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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