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HomoloGene:2775. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

NUMB,  H.sapiens
numb homolog (Drosophila)
NP_001005743.1
651 aa
NUMB,  P.troglodytes
numb homolog (Drosophila)
XP_001151152.2
640 aa
NUMB,  M.mulatta
numb homolog (Drosophila)
XP_001090008.1
652 aa
NUMB,  C.lupus
numb homolog (Drosophila)
XP_867854.1
658 aa
NUMB,  B.taurus
numb homolog (Drosophila)
NP_001095421.1
593 aa
Numb,  M.musculus
numb gene homolog (Drosophila)
NP_001129547.1
653 aa
Numb,  R.norvegicus
numb homolog (Drosophila)
NP_579821.1
592 aa
NUMB,  G.gallus
numb homolog (Drosophila)
NP_990166.1
582 aa
numb,  X.tropicalis
numb homolog
NP_001090828.1
643 aa
numb,  D.rerio
numb homolog (Drosophila)
NP_001035496.1
680 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Expression and function of NUMB in odontogenesis.
Li H, et al. Biomed Res Int 2013, 182965 (2013).
Numb expression and asymmetric versus symmetric cell division in distal embryonic lung epithelium.
El-Hashash AH & Warburton D. J Histochem Cytochem 60, 675-82 (2012).
[Numb expression in colon cancer and its significance].
Zeng YL, et al. Sichuan Da Xue Xue Bao Yi Xue Ban 43, 6-8, 14 (2012).
NUMB does not impair growth and differentiation status of experimental gliomas.
Euskirchen P, et al. Exp Cell Res 317, 2864-73 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PH-like (cl00273)
  Pleckstrin homology-like domain.
NumbF (pfam06311)
  NUMB domain.
NumbF (pfam06311)
  NUMB domain.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Numb includes H.sapiens NUMB and R.norvegicus Numb.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 11 species)
Actinopterygii - bony fishes (6 transcripts, 5 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

 

 

 

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