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HomoloGene:1549. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

GATA1,  H.sapiens
GATA binding protein 1 (globin transcription factor 1)
NP_002040.1
413 aa
GATA1,  P.troglodytes
GATA binding protein 1 (globin transcription factor 1)
XP_001139973.3
242 aa
LOC714631,  M.mulatta
erythroid transcription factor-like
XP_001104486.2
389 aa
GATA1,  C.lupus
GATA binding protein 1 (globin transcription factor 1)
XP_538026.2
412 aa
GATA1,  B.taurus
GATA binding protein 1 (globin transcription factor 1)
NP_001193169.1
413 aa
Gata1,  M.musculus
GATA binding protein 1
NP_032115.1
413 aa
LOC100911167,  R.norvegicus
erythroid transcription factor-like
XP_003752057.1
413 aa
Gata1,  R.norvegicus
GATA binding protein 1
NP_036896.1
413 aa
LOC100497467,  X.tropicalis
GATA-binding factor 1-A-like
XP_002944405.1
363 aa
gata1a,  D.rerio
GATA binding protein 1a
NP_571309.1
418 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Leukemia, megakaryoblastic, of Down syndrome.
Leukemia, megakaryoblastic, with or without Down syndrome.
Dyserythropoietic anemia with thrombocytopenia.
Macrothrombocytopenia.



Publications
Articles associated with genes and sequences of this homology group.

GATA-1 regulates the generation and function of basophils.
Nei Y, et al. Proc Natl Acad Sci U S A 110, 18620-5 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ZnF_GATA (cl00158)
  Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gata1 includes H.sapiens GATA1 and R.norvegicus Gata1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)
Actinopterygii - bony fishes (8 transcripts, 7 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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