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HomoloGene:18358. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TIGIT,  H.sapiens
T cell immunoreceptor with Ig and ITIM domains
NP_776160.2
244 aa
TIGIT,  P.troglodytes
T cell immunoreceptor with Ig and ITIM domains
XP_526270.4
311 aa
TIGIT,  C.lupus
T cell immunoreceptor with Ig and ITIM domains
XP_545108.4
294 aa
TIGIT,  B.taurus
T cell immunoreceptor with Ig and ITIM domains
XP_005201418.1
243 aa
Tigit,  M.musculus
T cell immunoreceptor with Ig and ITIM domains
NP_001139797.1
241 aa
Tigit,  R.norvegicus
T cell immunoreceptor with Ig and ITIM domains
XP_003751099.1
241 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR.
Stanietsky N, et al. Eur J Immunol 43, 2138-50 (2013).
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions.
Joller N, et al. J Immunol 186, 1338-42 (2011).
The TIGIT/CD226 axis regulates human T cell function.
Lozano E, et al. J Immunol 188, 3869-75 (2012).
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity.
Stanietsky N, et al. Proc Natl Acad Sci U S A 106, 17858-63 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ig (cl11960)
  Immunoglobulin domain.
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tigit includes H.sapiens TIGIT and R.norvegicus RGD1563191.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (2 transcripts, 2 species)

 

 

 

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