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HomoloGene:20807. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

LGR5,  H.sapiens
leucine-rich repeat containing G protein-coupled receptor 5
NP_003658.1
907 aa
LGR5,  P.troglodytes
leucine-rich repeat containing G protein-coupled receptor 5
XP_003313909.1
907 aa
LGR5,  M.mulatta
leucine-rich repeat containing G protein-coupled receptor 5
XP_001117502.1
907 aa
LGR5,  B.taurus
leucine-rich repeat containing G protein-coupled receptor 5
NP_001179449.1
907 aa
Lgr5,  M.musculus
leucine rich repeat containing G protein coupled receptor 5
NP_034325.2
907 aa
Lgr5,  R.norvegicus
leucine rich repeat containing G protein coupled receptor 5
NP_001100254.1
907 aa
LGR5,  G.gallus
leucine-rich repeat containing G protein-coupled receptor 5
XP_425441.2
909 aa
lgr5,  X.tropicalis
leucine-rich repeat-containing G-protein coupled receptor 5
XP_002940219.2
902 aa
rk,  D.melanogaster
rickets
NP_476702.1
1360 aa
GPRRK,  A.gambiae
GPRRK
XP_317111.1
1257 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Characterization of Lgr5-positive epithelial cells in the murine thymus.
Vroegindeweij E, et al. Eur J Immunol 43, 1243-51 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
LRR_4 (pfam12799)
  Leucine Rich repeats (2 copies).
LRR_8 (pfam13855)
  Leucine rich repeat.
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).
7TM_GPCR_Srx (pfam10328)
  Serpentine type 7TM GPCR chemoreceptor Srx.
LRRNT (cl02423)
  Leucine rich repeat N-terminal domain.
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).
7TM_GPCR_Srx (pfam10328)
  Serpentine type 7TM GPCR chemoreceptor Srx.
LRR_8 (pfam13855)
  Leucine rich repeat.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lgr5 includes H.sapiens LGR5 and R.norvegicus Lgr5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 7 species)
Amphibia - amphibians (3 transcripts, 2 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (3 transcripts, 3 species)

 

 

 

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