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HomoloGene:2126. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

PTPRC,  H.sapiens
protein tyrosine phosphatase, receptor type, C
1306 aa
PTPRC,  P.troglodytes
protein tyrosine phosphatase, receptor type, C
1306 aa
PTPRC,  C.lupus
protein tyrosine phosphatase, receptor type, C
1308 aa
PTPRC,  B.taurus
protein tyrosine phosphatase, receptor type, C
1145 aa
Ptprc,  M.musculus
protein tyrosine phosphatase, receptor type, C
1293 aa
Ptprc,  R.norvegicus
protein tyrosine phosphatase, receptor type, C
1273 aa
PTPRC,  G.gallus
protein tyrosine phosphatase, receptor type, C
1237 aa
ptprc,  X.tropicalis
protein tyrosine phosphatase, receptor type, C
1120 aa
ptprc,  D.rerio
protein tyrosine phosphatase, receptor type, C
1355 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Multiple sclerosis, susceptibility to.
Severe combined immunodeficiency due to PTPRC deficiency.
Hepatitic C virus, susceptibility to.

Articles associated with genes and sequences of this homology group.

CD45-deficient severe combined immunodeficiency caused by uniparental disomy.
Roberts JL, et al. Proc Natl Acad Sci U S A 109, 10456-61 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PTP_N (pfam12453)
  Protein tyrosine phosphatase N terminal.
CD45 (pfam12567)
  Leukocyte receptor CD45.
PHA03255 (PHA03255)
  BDLF3; Provisional.
PTPc (smart00194)
  Protein tyrosine phosphatase, catalytic domain.
PTPc (cd00047)
  Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
DUF3246 (pfam11596)
  Protein of unknown function (DUF3246).
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ptprc includes H.sapiens PTPRC and R.norvegicus Ptprc.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (9 transcripts, 8 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)




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