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HomoloGene:37276. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

LHCGR,  H.sapiens
luteinizing hormone/choriogonadotropin receptor
NP_000224.2
699 aa
LHCGR,  P.troglodytes
luteinizing hormone/choriogonadotropin receptor
XP_003309053.1
699 aa
LHCGR,  M.mulatta
luteinizing hormone/choriogonadotropin receptor
XP_001114090.1
703 aa
LHCGR,  C.lupus
luteinizing hormone/choriogonadotropin receptor
XP_538486.2
704 aa
LHCGR,  B.taurus
luteinizing hormone/choriogonadotropin receptor
NP_776806.1
701 aa
Lhcgr,  M.musculus
luteinizing hormone/choriogonadotropin receptor
NP_038610.1
700 aa
Lhcgr,  R.norvegicus
luteinizing hormone/choriogonadotropin receptor
NP_037110.1
700 aa
LHCGR,  G.gallus
luteinizing hormone/choriogonadotropin receptor
NP_990267.1
728 aa
lhcgr,  X.tropicalis
luteinizing hormone/choriogonadotropin receptor
XP_002935423.2
654 aa
lhcgr,  D.rerio
luteinizing hormone/choriogonadotropin receptor
NP_991188.1
708 aa
Lgr1,  D.melanogaster
Lgr1
NP_524393.2
831 aa
GPRFSH,  A.gambiae
GPRFSH
XP_309589.2
959 aa
fshr-1,  C.elegans
fshr-1
NP_505548.1
929 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hypogonadotropic hypogonadism.
Leydig cell adenoma, with precocious puberty.
Micropenis.
Pseudohermaphroditism, male, with Leydig cell hypoplasia.
Precocious puberty, male.



Publications
Articles associated with genes and sequences of this homology group.

Inactivating mutations of the human luteinizing hormone receptor in both sexes.
Latronico AC & Arnhold IJ. Semin Reprod Med 30, 382-6 (2012).
Luteinizing hormone receptor splicing variants in bovine Leydig cells.
Ma TH, et al. Genet Mol Res 11, 1721-30 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
GnHR_trans (pfam12369)
  Gonadotropin hormone receptor transmembrane region.
LRR_5 (pfam13306)
  Leucine rich repeats (6 copies).
LRR_8 (pfam13855)
  Leucine rich repeat.
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).
LRR_5 (pfam13306)
  Leucine rich repeats (6 copies).
LRR_8 (pfam13855)
  Leucine rich repeat.
SLAIN (pfam15301)
  SLAIN motif-containing family.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lhcgr includes H.sapiens LHCGR and R.norvegicus Lhcgr.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (7 transcripts, 6 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)

Arthropoda
Insecta - insects (3 transcripts, 3 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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