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HomoloGene:1166. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

HCRT,  H.sapiens
hypocretin (orexin) neuropeptide precursor
NP_001515.1
131 aa
HCRT,  P.troglodytes
hypocretin (orexin) neuropeptide precursor
XP_001166578.1
130 aa
HCRT,  M.mulatta
hypocretin (orexin) neuropeptide precursor
XP_001108991.1
131 aa
HCRT,  C.lupus
hypocretin (orexin) neuropeptide precursor
NP_001029166.1
130 aa
HCRT,  B.taurus
hypocretin (orexin) neuropeptide precursor
NP_001159992.1
131 aa
Hcrt,  M.musculus
hypocretin
NP_034540.1
130 aa
Hcrt,  R.norvegicus
hypocretin
NP_037311.1
130 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Narcolepsy.



Publications
Articles associated with genes and sequences of this homology group.

[Hypothalamic orexin system regulates energy and glucose metabolism].
Tsuneki H & Sasaoka T. Nihon Yakurigaku Zasshi 142, 316-7 (2013).
The orexigenic effect of orexin-A revisited: dependence of an intact growth hormone axis.
Álvarez-Crespo M, et al. Endocrinology 154, 3589-98 (2013).
Reduced orexin-A levels in frontotemporal dementia: possible association with sleep disturbance.
Çoban A, et al. Am J Alzheimers Dis Other Demen 28, 606-11 (2013).
Role of the medial prefrontal cortex in cataplexy.
Oishi Y, et al. J Neurosci 33, 9743-51 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Orexin (pfam02072)
  Prepro-orexin.
Orexin (pfam02072)
  Prepro-orexin.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hcrt includes H.sapiens HCRT and R.norvegicus HcRt.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 7 species)
Aves - birds (2 transcripts, 2 species)

 

 

 

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