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HomoloGene:4032. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

HOXA1,  H.sapiens
homeobox A1
NP_005513.1
335 aa
HOXA1,  P.troglodytes
homeobox A1
XP_519009.1
335 aa
HOXA1,  M.mulatta
homeobox A1
XP_001093148.1
335 aa
HOXA1,  C.lupus
homeobox A1
XP_005628713.1
333 aa
HOXA1,  B.taurus
homeobox A1
NP_001193040.1
333 aa
Hoxa1,  M.musculus
homeobox A1
NP_034579.3
336 aa
LOC100911406,  R.norvegicus
homeobox protein Hox-A1-like
XP_003752224.1
334 aa
Hoxa1,  R.norvegicus
homeo box A1
NP_037207.1
333 aa
HOXA1,  G.gallus
homeobox A1
XP_003640745.1
320 aa
hoxa1,  X.tropicalis
homeobox A1
NP_001008017.1
323 aa
hoxa1a,  D.rerio
homeo box A1a
NP_571611.1
329 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Athabaskan brainstem dysgenesis syndrome.
Bosley-Salih-Alorainy syndrome.



Publications
Articles associated with genes and sequences of this homology group.

HOXA1 mutations are not a common cause of Möbius syndrome.
Rankin JK, et al. J AAPOS 14, 78-80 (2010).
The clinical spectrum of homozygous HOXA1 mutations.
Bosley TM, et al. Am J Med Genet A 146A, 1235-40 (2008).
Clinical characterization of the HOXA1 syndrome BSAS variant.
Bosley TM, et al. Neurology 69, 1245-53 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
COG5576 (COG5576)
  Homeodomain-containing transcription factor [Transcription].
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hoxa1 includes H.sapiens HOXA1 and R.norvegicus Hoxa1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 7 species)
Actinopterygii - bony fishes (5 transcripts, 5 species)
Amphibia - amphibians (3 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

 

 

 

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