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HomoloGene:11052. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

C10orf2,  H.sapiens
chromosome 10 open reading frame 2
NP_068602.2
684 aa
C10H10orf2,  P.troglodytes
progressive external ophthalmoplegia 1
XP_003951780.1
277 aa
C9H10orf2,  M.mulatta
chromosome 10 open reading frame 2
XP_001109287.1
684 aa
C28H10orf2,  C.lupus
chromosome 28 open reading frame, human C10orf2
XP_543974.1
684 aa
C26H10orf2,  B.taurus
chromosome 26 open reading frame, human C10orf2
NP_001091933.1
683 aa
Peo1,  M.musculus
progressive external ophthalmoplegia 1 (human)
NP_722491.2
685 aa
Peo1,  R.norvegicus
progressive external ophthalmoplegia 1
NP_001101069.1
683 aa
PEO1,  G.gallus
progressive external ophthalmoplegia 1
NP_001026515.1
669 aa
LOC100491229,  X.tropicalis
chromosome unknown open reading frame, human C10orf2
XP_002938766.1
677 aa
peo1,  D.rerio
progressive external ophthalmoplegia 1
NP_001264527.1
728 aa
CG5924,  D.melanogaster
CG5924
NP_609318.1
613 aa
AgaP_AGAP010720,  A.gambiae
AgaP_AGAP010720
XP_311434.3
238 aa
F46G11.1,  C.elegans
F46G11.1
NP_508973.3
595 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Sensory ataxia neuropathy, dysarthria, and ophthalmoparesis.
Progressive external ophthalmoplegia with mitochondrial DNA deletions.
progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 3.



Publications
Articles associated with genes and sequences of this homology group.

Effect of bezafibrate treatment on late-onset mitochondrial myopathy in mice.
Yatsuga S & Suomalainen A. Hum Mol Genet 21, 526-35 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
P-loop_NTPase (cl09099)
  P-loop containing Nucleoside Triphosphate Hydrolases.
TOPRIM (cl00718)
  Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from ...
RecA-like_NTPases (cl17233)
  RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Peo1 includes H.sapiens C10orf2 and R.norvegicus Peo1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 9 species)
Actinopterygii - bony fishes (3 transcripts, 2 species)
Aves - birds (3 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 6 species)
Arachnida - arachnids (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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