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HomoloGene:21113. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MYO1A,  H.sapiens
myosin IA
NP_001242970.1
1043 aa
MYO1A,  P.troglodytes
myosin IA
XP_003313620.1
1043 aa
MYO1A,  M.mulatta
myosin IA
XP_001115546.1
1043 aa
MYO1A,  C.lupus
myosin IA
XP_531642.2
1041 aa
MYO1A,  B.taurus
myosin IA
NP_776820.1
1043 aa
Myo1a,  M.musculus
myosin IA
NP_001074688.1
1043 aa
Myo1a,  R.norvegicus
myosin IA
NP_062197.1
1043 aa
MYO1A,  G.gallus
myosin IA
NP_990494.1
1045 aa
myo1a,  X.tropicalis
myosin IA
NP_001008063.1
1073 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Deafness, autosomal dominant nonsyndromic sensorineural.



Publications
Articles associated with genes and sequences of this homology group.

Brush border myosin Ia inactivation in gastric but not endometrial tumors.
Mazzolini R, et al. Int J Cancer 132, 1790-9 (2013).
Control of cell membrane tension by myosin-I.
Nambiar R, et al. Proc Natl Acad Sci U S A 106, 11972-7 (2009).
Myosin-1a powers the sliding of apical membrane along microvillar actin bundles.
McConnell RE & Tyska MJ. J Cell Biol 177, 671-81 (2007).
From transcription to transport: emerging roles for nuclear myosin I.
Hofmann WA, et al. Biochem Cell Biol 84, 418-26 (2006).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IQ (cl15479)
  IQ calmodulin-binding motif.
Myosin_TH1 (pfam06017)
  Myosin tail.
Myosin_TH1 (pfam06017)
  Myosin tail.
Motor_domain (cl00286)
  Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes.
IQ (cl15479)
  Calmodulin-binding motif.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Myo1a includes H.sapiens MYO1A and R.norvegicus Myo1a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 8 species)
Aves - birds (3 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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