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HomoloGene:10715. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

GJC2,  H.sapiens
gap junction protein, gamma 2, 47kDa
NP_065168.2
439 aa
GJC2,  P.troglodytes
gap junction protein, gamma 2, 47kDa
XP_001145449.1
439 aa
GJC2,  M.mulatta
gap junction protein, gamma 2, 47kDa
XP_001083576.2
497 aa
GJC2,  C.lupus
gap junction protein, gamma 2, 47kDa
XP_005628409.1
434 aa
GJC2,  B.taurus
gap junction protein, gamma 2, 47kDa
NP_001039905.1
429 aa
Gjc2,  M.musculus
gap junction protein, gamma 2
NP_536702.3
440 aa
Gjc2,  R.norvegicus
gap junction protein, gamma 2
NP_001094254.1
440 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Pelizaeus-Merzbacher-like disease, autosomal recessive.



Publications
Articles associated with genes and sequences of this homology group.

GJC2 missense mutations cause human lymphedema.
Ferrell RE, et al. Am J Hum Genet 86, 943-8 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Connexin (cl02435)
  Connexin.
Connexin_CCC (cl11207)
  Gap junction channel protein cysteine-rich domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gjc2 includes H.sapiens GJC2 and R.norvegicus Gjc2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 6 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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