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HomoloGene:117451. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

FBXW7,  H.sapiens
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
NP_361014.1
707 aa
FBXW7,  P.troglodytes
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
XP_001153672.1
707 aa
FBXW7,  M.mulatta
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
XP_001084190.1
707 aa
FBXW7,  C.lupus
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
XP_867701.2
712 aa
FBXW7,  B.taurus
F-box and WD repeat domain containing 7
NP_001069717.1
627 aa
Fbxw7,  M.musculus
F-box and WD-40 domain protein 7
NP_001171245.1
710 aa
Fbxw7,  R.norvegicus
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
XP_002729135.2
713 aa
FBXW7,  G.gallus
F-box and WD repeat domain containing 7
XP_420447.4
773 aa
fbxw7,  X.tropicalis
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
XP_002933527.2
735 aa
fbxw7,  D.rerio
F-box and WD repeat domain containing 7
XP_005171007.1
606 aa
AgaP_AGAP005359,  A.gambiae
AgaP_AGAP005359
XP_315369.4
1456 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Prognostic significance of Fbw7 in human melanoma and its role in cell migration.
Cheng Y, et al. J Invest Dermatol 133, 1794-802 (2013).
[Expression of Fbxw7 and its correlation with cell proliferation in human hepatocellular carcinoma].
Zhou ZY, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 28, 1303-6 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
WD40 (cd00200)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
F-box (cl02535)
  F-box domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fbxw7 includes H.sapiens FBXW7.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (19 transcripts, 12 species)
Aves - birds (5 transcripts, 3 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Actinopterygii - bony fishes (4 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)

Arthropoda
Insecta - insects (4 transcripts, 4 species)
Arachnida - arachnids (2 transcripts, 2 species)
Maxillopoda - crustaceans (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Ascomycota
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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