Display Settings:

Format

Send to:

Choose Destination

Links from PubMed

HomoloGene:8653. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SACS,  H.sapiens
sacsin molecular chaperone
NP_055178.3
4579 aa
SACS,  P.troglodytes
spastic ataxia of Charlevoix-Saguenay (sacsin)
XP_001174272.3
4722 aa
SACS,  M.mulatta
spastic ataxia of Charlevoix-Saguenay (sacsin)
XP_001089964.2
4517 aa
SACS,  C.lupus
spastic ataxia of Charlevoix-Saguenay (sacsin)
XP_005635602.1
4578 aa
SACS,  B.taurus
spastic ataxia of Charlevoix-Saguenay (sacsin)
XP_005213880.1
4587 aa
Sacs,  R.norvegicus
spastic ataxia of Charlevoix-Saguenay (sacsin)
XP_006252229.1
4590 aa
SACS,  G.gallus
spastic ataxia of Charlevoix-Saguenay (sacsin)
XP_004938853.1
4580 aa
sacs,  X.tropicalis
spastic ataxia of Charlevoix-Saguenay (sacsin)
XP_004912121.1
4578 aa
sacs,  D.rerio
spastic ataxia of Charlevoix-Saguenay (sacsin)
XP_005157537.1
4587 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Spastic ataxia, Charlevoix-Saguenay type.



Publications
Articles associated with genes and sequences of this homology group.

The ARSACS phenotype can include supranuclear gaze palsy and skin lipofuscin deposits.
Stevens JC, et al. J Neurol Neurosurg Psychiatry 84, 114-6 (2013).
Retinal nerve fibre layer thickness in ARSACS: myelination or hypertrophy?
Garcia-Martin E, et al. Br J Ophthalmol 97, 238-41 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ubiquitin (pfam00240)
  Ubiquitin family.
DnaJ (cl02542)
  DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
UBQ (cl00155)
  Ubiquitin-like proteins.
HEPN (cl00824)
  Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN [Function unknown]
DnaJ (cl02542)
  DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 8 species)
Actinopterygii - bony fishes (7 transcripts, 4 species)
Aves - birds (4 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

 

 

 

Support Center