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HomoloGene:40076. Gene conserved in Saccharomycetaceae Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

RAP1,  S.cerevisiae
827 aa
KLLA0D19294g,  K.lactis
666 aa
AGOS_ABL180W,  E.gossypii
681 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Effect of Rap1 binding on DNA distortion and potassium permanganate hypersensitivity.
Le Bihan YV, et al. Acta Crystallogr D Biol Crystallogr 69, 409-19 (2013).
Promoter elements regulate cytoplasmic mRNA decay.
Bregman A, et al. Cell 147, 1473-83 (2011).
Solution structure of Rap1 BRCT domain from Saccharomyces cerevisiae reveals a novel fold.
Zhang W, et al. Biochem Biophys Res Commun 404, 1055-9 (2011).
Rap1 prevents telomere fusions by nonhomologous end joining.
Pardo B & Marcand S. EMBO J 24, 3117-27 (2005).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
BRCT (cl00038)
  Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks.
rap1_RCT (cl13131)
  The RAP1 (repressor activator protein 1) C-terminal domain (RCT) mediates interactions with other proteins such as TRF2 (human), Rif1, Rif2, Sir3, Sir4 (Saccharomyces cerevisiae), and Taz1 (Schizosaccharomyces pombe) at telomeres and other loci. RAP1, identified in budding yeast as repressor/activator protein 1, is a well-conserved telomere binding protein, also found in fission yeast and mammals. In Saccharomyces cerevisiae, RAP1 directly binds DNA and is involved in transcriptional activation, gene silencing, as well as binding at numerous sites at each telemore, where it functions in telomere length regulation, telomeric position effect gene silencing and telomere end protection. Human RAP1 apparently does not bind telomeric DNA directly, but binds telomere repeat binding factor 2 (TRF2) via the RCT. RAP1 might act by suppressing nonhomologous end-joining. Yeast RAP1 has two myb-type DNA binding modules, and an RCT domain that recruits Sir proteins 3 and 4 (Sir3, Sir4) for gene silencing, and Rif1 and Rif2 for telomere length maintenance. Schizosaccharomyces pombe RAP1 (spRap1), like human RAP1, lacks direct DNA-binding activity and is localized to telomeres via Taz1, an ortholog of TRF1 and TRF2. The S. pompe RCT resembles the first 3-helix bundle of the yeast and human RCT forms, but is not included in this larger model.
rap1_myb-like (cl17454)
  DNA-binding modules of yeast Rap1 and related proteins.




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