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HomoloGene:32426. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SEMA6A,  H.sapiens
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
NP_065847.1
1030 aa
SEMA6A,  P.troglodytes
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
XP_001151177.1
1030 aa
SEMA6A,  M.mulatta
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
XP_002804530.1
971 aa
SEMA6A,  C.lupus
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
XP_858843.1
1030 aa
SEMA6A,  B.taurus
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
NP_001180138.1
1029 aa
Sema6a,  M.musculus
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
NP_061214.2
1031 aa
Sema6a,  R.norvegicus
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
XP_003751830.1
1048 aa
SEMA6A,  G.gallus
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
XP_003643120.1
1044 aa
sema6a,  X.tropicalis
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
XP_002931763.2
1025 aa
sema6a,  D.rerio
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
NP_956286.1
968 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

A role of Sema6A expressed in oligodendrocyte precursor cells.
Okada A & Tomooka Y. Neurosci Lett 539, 48-53 (2013).
Semaphorin 6A regulates angiogenesis by modulating VEGF signaling.
Segarra M, et al. Blood 120, 4104-15 (2012).
From plasma membrane to cytoskeleton: a novel function for semaphorin 6A.
Prislei S, et al. Mol Cancer Ther 7, 233-41 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PSI (pfam01437)
  Plexin repeat.
PSI (cl02601)
  A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas shows 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).
Sema (cl15693)
  The Sema domain, a protein interacting module, of semaphorins and plexins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sema6a includes H.sapiens SEMA6A and R.norvegicus Sema6a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 8 species)
Actinopterygii - bony fishes (7 transcripts, 4 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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