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HomoloGene:30997. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

IGF1R,  H.sapiens
insulin-like growth factor 1 receptor
NP_000866.1
1367 aa
IGF1R,  P.troglodytes
insulin-like growth factor 1 receptor
XP_510613.2
1364 aa
IGF1R,  M.mulatta
insulin-like growth factor 1 receptor
XP_001100407.1
1367 aa
IGF1R,  C.lupus
insulin-like growth factor 1 receptor
XP_545828.2
1367 aa
IGF1R,  B.taurus
insulin-like growth factor 1 receptor
NP_001231541.1
1367 aa
Igf1r,  M.musculus
insulin-like growth factor I receptor
NP_034643.2
1369 aa
Igf1r,  R.norvegicus
insulin-like growth factor 1 receptor
NP_434694.1
1370 aa
IGF1R,  G.gallus
insulin-like growth factor 1 receptor
NP_990363.1
1363 aa
igf1r,  X.tropicalis
insulin-like growth factor 1 receptor
XP_002933351.1
1362 aa
igf1ra,  D.rerio
insulin-like growth factor 1a receptor
NP_694500.1
1405 aa
igf1rb,  D.rerio
insulin-like growth factor 1b receptor
NP_694501.1
1380 aa
InR,  D.melanogaster
Insulin-like receptor
NP_001138093.1
2144 aa
INR,  A.gambiae
INR
XP_320130.3
1318 aa
daf-2,  C.elegans
daf-2
NP_497650.4
1846 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Intrauterine and postnatal growth retardation.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Recep_L_domain (pfam01030)
  Receptor L domain.
FU (cl00066)
  Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Furin-like (pfam00757)
  Furin-like cysteine rich region.
Recep_L_domain (pfam01030)
  Receptor L domain.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Igf1r includes H.sapiens IGF1R and R.norvegicus Igf1r.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 16 species)
Actinopterygii - bony fishes (14 transcripts, 7 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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