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HomoloGene:55643. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

KRT8,  H.sapiens
keratin 8
NP_001243211.1
511 aa
LOC464613,  P.troglodytes
keratin, type II cytoskeletal 8-like
XP_520149.3
749 aa
KRT8,  M.mulatta
keratin 8
XP_001090336.2
481 aa
KRT8,  C.lupus
keratin 8
XP_543639.4
491 aa
KRT8,  B.taurus
keratin 8
NP_001028782.1
478 aa
Krt8,  M.musculus
keratin 8
NP_112447.2
490 aa
Krt8,  R.norvegicus
keratin 8
NP_955402.1
483 aa
krt8,  X.tropicalis
keratin 8
NP_001002797.1
508 aa
krt8,  D.rerio
keratin 8
NP_956374.1
520 aa
krt5,  D.rerio
keratin 5
NP_571231.1
558 aa
krt4,  D.rerio
keratin 4
NP_571584.1
498 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cirrhosis, cryptogenic.
Cirrhosis, noncryptogenic, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Keratin 8 variants are associated with cryptogenic hepatitis.
Zierden M, et al. Virchows Arch 460, 389-97 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
phage_LysB (TIGR03495)
  phage lysis regulatory protein, LysB family.
Filament (pfam00038)
  Intermediate filament protein.
DUF883 (cl01888)
  Bacterial protein of unknown function (DUF883).
DUF4349 (pfam14257)
  Domain of unknown function (DUF4349).
HAUS2 (pfam15003)
  HAUS augmin-like complex subunit 2.
Prefoldin (cl09111)
  Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Krt8 includes H.sapiens KRT8 and R.norvegicus Krt8.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 12 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Amphibia - amphibians (4 transcripts, 2 species)

 

 

 

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