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HomoloGene:2455. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

LBR,  H.sapiens
lamin B receptor
NP_919424.1
615 aa
LBR,  P.troglodytes
lamin B receptor
XP_001137563.1
615 aa
LBR,  M.mulatta
lamin B receptor
XP_001094360.1
615 aa
LBR,  C.lupus
lamin B receptor
XP_547512.2
618 aa
LBR,  B.taurus
lamin B receptor
NP_001093799.1
621 aa
Lbr,  M.musculus
lamin B receptor
NP_598576.2
626 aa
Lbr,  R.norvegicus
lamin B receptor
NP_604448.1
620 aa
LBR,  G.gallus
lamin B receptor
NP_990673.1
637 aa
lbr,  D.rerio
lamin B receptor
NP_001002720.1
619 aa
LBR,  D.melanogaster
Lamin B receptor
NP_726115.1
716 aa
ERG24,  S.cerevisiae
ERG24
NP_014119.1
438 aa
KLLA0C12265g,  K.lactis
KLLA0C12265g
XP_452744.1
441 aa
AGOS_AFR346W,  E.gossypii
AGOS_AFR346W
NP_985893.2
438 aa
erg24,  S.pombe
erg24
NP_596767.1
424 aa
MGG_13986,  M.oryzae
MGG_13986
XP_003716043.1
480 aa
NCU08762,  N.crassa
NCU08762
XP_956111.1
490 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Pelger-Huet anomaly.
Greenberg dysplasia.



Publications
Articles associated with genes and sequences of this homology group.

Pelger-huet anomaly and a mild skeletal phenotype secondary to mutations in LBR.
Borovik L, et al. Am J Med Genet A 161A, 2066-73 (2013).
Nuclear shape in papillary thyroid carcinoma: a role for lamin B receptor?
Recupero D, et al. Rom J Morphol Embryol 51, 615-20 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
LBR_tudor (pfam09465)
  Lamin-B receptor of TUDOR domain.
PEMT (cl00763)
  Phospholipid methyltransferase.
ERG4_ERG24 (pfam01222)
  Ergosterol biosynthesis ERG4/ERG24 family.
ERG4_ERG24 (pfam01222)
  Ergosterol biosynthesis ERG4/ERG24 family.
TUDOR (cl02573)
  Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lbr includes H.sapiens LBR and R.norvegicus Lbr.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 11 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 3 species)
Eurotiomycetes - ascomycetes (2 transcripts, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

 

 

 

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