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HomoloGene:40825. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SIRT5,  H.sapiens
sirtuin 5
NP_036373.1
310 aa
SIRT5,  P.troglodytes
sirtuin 5
XP_001169506.1
310 aa
SIRT5,  M.mulatta
sirtuin 5
XP_001091987.1
310 aa
SIRT5,  C.lupus
sirtuin 5
XP_535891.2
310 aa
SIRT5,  B.taurus
sirtuin 5
NP_001029467.1
310 aa
Sirt5,  M.musculus
sirtuin 5
NP_849179.1
310 aa
Sirt5,  R.norvegicus
sirtuin 5
NP_001004256.1
310 aa
SIRT5,  G.gallus
sirtuin 5
NP_001263293.1
309 aa
sirt5,  X.tropicalis
sirtuin 5
NP_001263631.1
309 aa
sirt5,  D.rerio
sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)
NP_001002605.1
305 aa
AGOS_ABL004W,  E.gossypii
AGOS_ABL004W
NP_982943.1
319 aa
MGG_15048,  M.oryzae
MGG_15048
XP_003721315.1
357 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Mitochondrial sirtuins: regulators of protein acylation and metabolism.
He W, et al. Trends Endocrinol Metab 23, 467-76 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SIR2 (cl00195)
  SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sirt5 includes H.sapiens SIRT5 and R.norvegicus Sirt5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (20 transcripts, 10 species)
Mammalia - mammals (16 transcripts, 12 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (4 transcripts, 3 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Coniferopsida - conifers (2 transcripts, 2 species)
Bryopsida - mosses (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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